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Database: UniProt
Entry: A0A2K6GH41_PROCO
LinkDB: A0A2K6GH41_PROCO
Original site: A0A2K6GH41_PROCO 
ID   A0A2K6GH41_PROCO        Unreviewed;       573 AA.
AC   A0A2K6GH41;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
GN   Name=SLC40A1 {ECO:0000313|Ensembl:ENSPCOP00000025552.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000025552.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000025552.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC       {ECO:0000256|RuleBase:RU365065}.
CC   -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU365065}.
CC   -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC       subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC       ECO:0000256|RuleBase:RU365065}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU365065}.
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DR   RefSeq; XP_012519102.1; XM_012663648.1.
DR   RefSeq; XP_012519103.1; XM_012663649.1.
DR   AlphaFoldDB; A0A2K6GH41; -.
DR   STRING; 379532.ENSPCOP00000025552; -.
DR   Ensembl; ENSPCOT00000036246.1; ENSPCOP00000025552.1; ENSPCOG00000025015.1.
DR   GeneID; 105825767; -.
DR   KEGG; pcoq:105825767; -.
DR   CTD; 30061; -.
DR   GeneTree; ENSGT00390000015143; -.
DR   OMA; NIGNWVD; -.
DR   OrthoDB; 38357at2759; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
DR   GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:Ensembl.
DR   CDD; cd17480; MFS_SLC40A1_like; 1.
DR   InterPro; IPR009716; Ferroportin-1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR   PANTHER; PTHR11660:SF47; SOLUTE CARRIER FAMILY 40 MEMBER 1; 1.
DR   Pfam; PF06963; FPN1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|RuleBase:RU365065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT   TRANSMEM        58..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        95..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        122..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        307..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        339..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        374..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        521..541
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
SQ   SEQUENCE   573 AA;  62870 MW;  2AE74796273B2365 CRC64;
     MTRARDQNRQ GGCCGSLAKY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNNLLL
     TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MIVFLYKNEL
     LTMYHGWVLT SCYILIITIA NIANLASTAT TITIQRDWIV VVAGDDRSKL ADMNATVRRI
     DQLTNILAPM VVGQIMTFGS AVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK
     VEETELKQLN LHKDTEPNPL EGTHLMGEKD SNVHELEHEQ EPTCASQMAE PFRTFRDGWI
     SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA VTGIMGTVAF
     TWLRRKCGLV RTGLISGLAQ LSCLTLCVIS VFMPGSPLDL SVSPFEDIRS RFIPAESITP
     TKIPETAIIT EIYMSNGSDP ANTILETSPK PVPIISVSLL FAGVIAARVG LWSFDLTVTQ
     LLQENVIESE RGIINGVQNS MNYLLDLLHF IMVILAPNPE AFGLLVLISV SFVAMGHSMY
     FRFAQKTLGN QLFVCCPDTK EVRNENQANT SDV
//
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