ID A0A2K6GHI2_PROCO Unreviewed; 1180 AA.
AC A0A2K6GHI2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=INSR {ECO:0000313|Ensembl:ENSPCOP00000025686.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000025686.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000025686.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A2K6GHI2; -.
DR Ensembl; ENSPCOT00000036382.1; ENSPCOP00000025686.1; ENSPCOG00000025098.1.
DR GeneTree; ENSGT00940000155404; -.
DR OMA; FFILCTC; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00064; FU; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF535; INSULIN RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00261; FU; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT DOMAIN 600..702
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 876..1180
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 910
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1180 AA; 133741 MW; E2F580544107D967 CRC64;
PALHFLPLLV CPGMDIRNNL TRLHELENCS VIEGHLQILL MFKTRPEDFR DLSFPKLIMI
TDYLLLFRVY GLESLKDLFP NLTVIRGSRL FFNYALVIFE MVHLKELGLY NLMNITRGSV
RIEKNNELCY LATIDWSRIL DSVEDNYIVL NKDDNEECGD ICPGTAKGKT NCPATVINGQ
FVERCWTHSH CQKVCPTICK SHGCTAEGLC CHSECLGNCS EPDDPTKCVA CRNFYLDGRC
VETCPPPYYH FQDWRCVNFS FCQDLHNKCK NSRRQGCHQY VIHNNKCIPE CPSGYTMNSS
NLVCTPCLGP CPKVCHILEG EKTIDSVTSA QELRGCTVVN GSLIINIRGG NNLAAELEAN
LGLIEEISGY LKIRRSYALV SLSFFRKLRL IRGETLEMGS YSFYALDNQN LRQLWDWSKH
NLTITQGKLF FHYNPKLCLS EIHKMEEVSG TKGRQERNDI ALKTNGDQAS CENELLKFSY
IRTSFDKILL KWEPYWPPDF RDLLGFMLFY KEAPYQNVTE FDGQDACGSN SWTVVDVDPP
LRSNDPKLQN HPGWLMRGLK PWTQYAIFVK TLVTFSDERR TYGAKSDIIY VQTNATNPSV
PLDPISVSNS SSQILLKWKP PSDPNGNITH YLVFWERQAE DSELFELDYC LKGLKLPSRT
WSPPFESDDS QKHNQSGYED SAGECCACPK TDSQILKELE ESSFRKTFED YLHNVVFVPR
PSRKRRSLGD VGNVTVAAVP TVPSFPNISS TTAPTSPEEH RPFEKVVNKE SLVISGLRHF
TGYRIELQAC NQDAPEERCS VAAYVSARTM PEAKADDIVG PVTHEIFENN VVHLMWQEPK
EPNGLIVLYE VSYRRYVVFP CSVYVPDEWE VPREKITLLR ELGQGSFGMV YEGNARDIVK
GEAETRVAVK TVNESSSLRE RIEFLNEASV MKGFTCHHVV RLLGVVSKGQ PTLVVMELMA
HGDLKSYLRS LRPEAENNPG RPPPTLQEMI QMAAEIADGM AYLNAKKFVH RDLAARNCMV
AHDFTVKIGG LSGFLAPLSV GSHALPGLHA CQASPGWGCE KAVPGQWSGE GHSSVLPEYR
SQSPPPGPAE PMMFRNCWNS WSKRPAERFR DERGGNKCGL IFTVNTFGRQ TYIFLFYFSR
RPIKYCKNYH RPPHLCLSLQ CGDWKYLLIP EKKVSAVVCS
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