ID   A0A2K6GJQ9_PROCO        Unreviewed;       367 AA.
AC   A0A2K6GJQ9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Protein NDRG2 {ECO:0000256|ARBA:ARBA00015427, ECO:0000256|RuleBase:RU367129};
GN   Name=NDRG2 {ECO:0000313|Ensembl:ENSPCOP00000026495.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000026495.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000026495.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Contributes to the regulation of the Wnt signaling pathway.
CC       Down-regulates CTNNB1-mediated transcriptional activation of target
CC       genes. May be involved in neuron differentiation.
CC       {ECO:0000256|RuleBase:RU367129}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, growth cone
CC       {ECO:0000256|ARBA:ARBA00004624}. Cytoplasm
CC       {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU367129}.
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000256|ARBA:ARBA00005598,
CC       ECO:0000256|RuleBase:RU367129}.
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DR   AlphaFoldDB; A0A2K6GJQ9; -.
DR   Ensembl; ENSPCOT00000037246.1; ENSPCOP00000026495.1; ENSPCOG00000025622.1.
DR   GeneTree; ENSGT00950000182872; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   PANTHER; PTHR11034; N-MYC DOWNSTREAM REGULATED; 1.
DR   PANTHER; PTHR11034:SF17; PROTEIN NDRG2; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367129};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU367129};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW   ECO:0000256|RuleBase:RU367129};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902,
KW   ECO:0000256|RuleBase:RU367129};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW   ECO:0000256|RuleBase:RU367129}.
FT   REGION          330..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   367 AA;  40332 MW;  BA6D560C03A2FE37 CRC64;
     MENGGSSRAT MAELQEVQIT EEKPLLPGQT PEAAKTHSVE TPYGSVTFTV YGTPKPKRPA
     IFTYHDVGLN YKSCFQPLFQ FGDMQEIIQN FVRVHVDAPG MEEGAPVFPL GYQYPSLDQL
     ADMIPCILQY LNFSTIIGVG VGAGAYILSR YALNHPDTVE GLVLINIDPN AKGWMDWAAH
     KLTGLTSSVA EMILGHLFSQ EELSRNSELI QKYRNIITHA PNLENIELYW NSYNNRRDLN
     FERGGDITLK CPVMLVVGDQ APHEDAVVEC NSKLDPTQTS FLKMADSGGQ PQLTQPGKLT
     EAFKYFLQGM GYMASSCMTR LSRSRTASLT SAASIDGNRS RSRTLSQSSE SGTLSSGPPG
     HTMEVSC
//