ID   A0A2K6GKB1_PROCO        Unreviewed;      1085 AA.
AC   A0A2K6GKB1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=BUB1 mitotic checkpoint serine/threonine kinase {ECO:0000313|Ensembl:ENSPCOP00000026647.1};
GN   Name=BUB1 {ECO:0000313|Ensembl:ENSPCOP00000026647.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000026647.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000026647.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6GKB1; -.
DR   STRING; 379532.ENSPCOP00000026647; -.
DR   Ensembl; ENSPCOT00000037409.1; ENSPCOP00000026647.1; ENSPCOG00000025717.1.
DR   GeneTree; ENSGT00940000157865; -.
DR   OMA; NCEKGVG; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000940; C:outer kinetochore; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140995; F:histone H2A kinase activity; IEA:Ensembl.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:Ensembl.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:Ensembl.
DR   GO; GO:2000720; P:positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric; IEA:Ensembl.
DR   CDD; cd14028; STKc_Bub1_vert; 1.
DR   Gene3D; 1.25.40.430; -; 1.
DR   Gene3D; 6.10.130.20; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR015661; Bub1/Mad3.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR013212; Mad3/Bub1_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR   PANTHER; PTHR14030:SF26; MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1; 1.
DR   Pfam; PF08311; Mad3_BUB1_I; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00777; Mad3_BUB1_I; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51489; BUB1_N; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT   DOMAIN          11..182
FT                   /note="BUB1 N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51489"
FT   DOMAIN          786..1085
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          538..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         820
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1085 AA;  123124 MW;  4F064AF786C00024 CRC64;
     MDNPENVFQM FEAHMQSYKG DDPLGEWESY MQWVEENFPE NKEYLTTLLE HLMKEFLDKK
     RYHNDPRFIN YCLKFAEYNS DLHQFFEFLY NHGIGTLSSL LYVAWAEHLE AQGELQHASA
     VFRRGIQNQA EPRELLQQQY RLFQTRLTET HLSAQARTSE PLHNAQILNQ IIASKSNPGN
     NLACVSKNQG SELSGVISSA CDKESNIEQR VIMISKSEYS AHSSLAAKAH VQQVVMYCKE
     KLIRGESEFS FEELRAQKYN QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL
     HQVVETSHGD LPAIQERCEV NPACMGPSVG SQQELRAPCL PAINQQTSVN TRENARQAPP
     VDPLKTNVTP ASLVSPAISQ SIHPPVPFTA QSVTDSMFAV AGRDPGYVNK STYEFKPQNG
     ADIKEGYETY KIANTSSFHT TPNTSLGMVQ ATPSKGQPSP TVHTKEALGF IMNMFQAPTL
     PDISDDKDEW QSLDQNEDAF EAQFQKNARS SGAWGVNKII SSLSSAFSVF EDGNKENYGL
     PQPKNKPTGA RTFGERSISR FPSKPNEVPH TEEFLDDSTV WGIRCNKTLA PSPKSSGDFT
     RAAQLASTPF HKLPTESVHI LEDKENVVAK QCTHVTLDSC EENIVVPSKD RKFSPIREKS
     PEQAFPSDMY SASLLRQNQP AAGAVLTHEA ERGLEACKLT DTEIAIAEDP PDAVAGLQAE
     RMQTDSLGNV DAPNFTVENP WDDKLILKLL SGLSKPVNSY TNTFEWQCKL PAIKPKTEFQ
     LGSMQVYVHH LLGEGAFAQV YEATQGNVND TKSKEKFVLK VQKPANPWEF YIGTQLMDRL
     KPTMQHMFIK FYSAHLFQNG SVLVGDLYSY GTLLNAINLY KNTPEKVMPQ GLVISFAMRM
     LYMMEQVHDC EIIHGDIKPD NFILGNRFLE QDGEDDDLSA GLALIDLGQS IDMKLFPKGT
     IFTAKCETSG FQCIEMLSNR PWNYQIDYFG VAATIYCMLF GTYMKVKNEG GVWKPEGLFR
     RLPHLDMWNE FFHIMLNIPD CHHLPSLDLL RQKLKKVFQQ HYANKIRALR NRLIVLLLEY
     KRSRK
//