ID A0A2K6GKF6_PROCO Unreviewed; 3554 AA.
AC A0A2K6GKF6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=CUB and Sushi multiple domains 2 {ECO:0000313|Ensembl:ENSPCOP00000026692.1};
GN Name=CSMD2 {ECO:0000313|Ensembl:ENSPCOP00000026692.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000026692.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000026692.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR Ensembl; ENSPCOT00000037461.1; ENSPCOP00000026692.1; ENSPCOG00000025738.1.
DR GeneTree; ENSGT00940000159768; -.
DR OMA; TECLDTG; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 28.
DR CDD; cd00041; CUB; 13.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 28.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 14.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656:SF6; CUB AND SUSHI DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR Pfam; PF00431; CUB; 14.
DR Pfam; PF00084; Sushi; 27.
DR SMART; SM00032; CCP; 28.
DR SMART; SM00042; CUB; 14.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 28.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 14.
DR PROSITE; PS01180; CUB; 13.
DR PROSITE; PS50923; SUSHI; 28.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3478..3499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..131
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 134..195
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 199..303
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 338..399
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 402..513
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 516..573
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 575..683
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 686..747
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 749..857
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 862..919
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 921..1031
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1034..1093
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1095..1203
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1206..1266
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1268..1377
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1380..1440
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1442..1550
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1553..1614
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1699..1760
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1762..1870
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1873..1932
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1934..2042
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2045..2104
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2106..2217
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2216..2277
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2279..2390
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2390..2452
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2453..2514
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2515..2579
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2580..2637
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2660..2717
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2718..2775
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2776..2838
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2839..2896
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2900..2957
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2958..3016
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3017..3076
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3077..3134
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3135..3192
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3196..3254
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3255..3314
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 544..571
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 890..917
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1268..1295
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2608..2635
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2688..2715
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2746..2773
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2809..2836
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2867..2894
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2928..2955
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2987..3014
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3105..3132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3163..3190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3225..3252
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 3554 AA; 386796 MW; 922E4548723EA792 CRC64;
AKIVWLCSER VWQVQRTEKG QNCTFQLHGP NGTVESPGFP YGYPNYANCT WTITAEDQHR
IQLVFQSFAL EEDFDVLSVF DGPPQPENLR TRLTGFQLPA TIVSAATTLS LRLISDYAVS
AQGFHASYEV LPSHTCGNPG RLTNGVQQGS TFNLGDKVRY SCNPGFFLEG HAVLTCHAGS
ENSATWDFPL PSCRADDACG GTLRGQSGII SSPHFPSEYH NNADCTWTIL AELGDTIALV
FIDFQLEDGY DFLEVTGTEG SSLWFTGASL PAPVISSKNW LRLHFTSDGN HRQRGFSAQY
QVKKQIELKS RGVKLMPSKD NSQKTSVLTQ VGVSQGHSMC PDPGIPERGK RLGSDFRLGS
SVQFTCNEGY DLQGSKRITC MKVSDMFAAW SDHRPVCRAR MCDAHLRGPS GIITSPNFPI
QYDNNAHCVW IITALNPAKV IKLAFEEFDL ERGYDTLTVG DGGQDGDQKT VLYVLTGTSV
PDLIVSTNHQ MWLLFQTDGS GSSLGFKASY EEIEQGSCGD PGIPAYGRRE GSRFRHGDTL
KFECQPAFEL VGQKAITCQK NNQWSAKKPG CVFSCFFNFT SPSGVVLSPN YPEDYGNHLH
CVWLILARPE SRIHLAFNDI DVEPQFDFLV IKDGATAEAP VLGTFSGNQL PSSITSSGHV
ARLEFQTDHS TGKRGFNITF TTFRHNECPD PGVPVNGKRF GDSLQLGSSI SFLCDEGFLG
TQGSETITCI LKEGSVVWNS AVLRCEAPCG GHLTSPSGTI LSPGWPGFYK DALSCAWVIE
AQPGYPIKIT FDRFKTEVNY DTLEVRDGRT YSAPLIGVYH GTQVPQFLIS TSNYLYLLFS
TDKSHSDIGF QLRYETITLQ SDHCLDPGIP VNGQRHGNDF YVGALVTFSC DSGYTLSDGE
PLECEPNFQW SRALPSCEAL CGGFIQGSSG TILSPGFPDF YPNNLNCTWI IETSHGKGVF
FTFHTFHLES GHDYLLITEN GSFTQPLRQL TGSRLPAPIS AGLYGNFTAQ VRFISDFSMS
YEGFNITFSE YDLEPCEEPE VPAYSIRKGL QFGVGDTLTF SCFPGYRLEG TARITCLGGR
RRLWSSPLPR CVAECGNSVT GTQGTLLSPN FPVNYNNNHE CIYSIQTQPG KGIQLKARAF
ELSEGDVLKV YDGNNNSARL LGVFSHSEMM GVTLNSTSSS LWLDFITDAE NTSKGFELQF
SSFELIKCED PGTPQFGYKV HDGGHFAGSS VSFSCDPGYS LRGSEELLCL SGERRTWDRP
LPTCVAECGG TVKGEVSGQV LSPGYPAPYE HNLNCIWIIE ADAGCTIGLH FLVFDTEEVH
DVLRIWDGPV ESGVLLKELS GPALPKDLHS TFNSVVLQFS TDFFTSKQGF AIQFSVSTAT
SCNDPGVPQN GSRSGDSWEA GDSTVFQCDP GYALQGSAEI SCVKIENRFF WQPSPPTCIA
PCGGDLTGPS GVILSPNYPE PYPPGKECDW KVTVSPDYVI ALVFNIFNLE PGYDFLHIYD
GRDSLSPLIG SFYGSQLPGR IESSSNSLFL AFRSDASVSN AGFVIDYTEN PRESCFDPGS
IKNGTRVGSD LKLGSSITYY CHGGYEVEGS STLSCILGSD GKPVWNNPRP VCTAVGEPVS
RVVFGQFAFF HTALNDVVEV HDGHSQHSRL LSSLSGSHTG ESLPLATSNQ VLIKFSAKGQ
VPARGFHFVY QAVPRTSATQ CSSVPEPRYG KRLGSDFSVG AVVRFECSSG YALQGSPEIE
CLPVPGALAQ WNVSAPTCVV PCGGNLTERR GTILSPGFPE PYLNSLNCVW KIMVPEGAGI
QIQVISFVTE QNWDSLEVFD GADNTVTMLG SFSGTTVPAL LNSTSNQLYL HFYSDISVSA
AGFHLEYKTV GLSSCPEPAV PSNGVKTGER YLVNDVVSFQ CEPGYALQGH AHISCMPGTV
RRWNYPPPLC IAQCGGTVEE MEGVILSPGF PGNYPSNMDC AWTIALPVGF GAHIQFLNFS
TEPNHDFIEI RNGPYETSRM MGRFSGSELP GSLLSTSHET TVYFHSDHSQ NRPGFKLEYQ
AYELQECPDP EPFANGIVRG AGYNVGQSVT FECLPGYQLI GHPVLTCQHG TNRNWDHPLP
RCEVPCGGNV TSSNGTVYSP GFPSPYSSSQ DCVWLITVPI GHGIRLNLSL LQTEPSGDFI
TVWDGPQQTA PRLGVFTRSL AKKTLHSSSN QVQLKFHRDA ATGGIFAIAF SAYPLTKCPP
PTILPNAEVV TENEEFNIGD IVRYRCLPGF TLVGSEILTC KLGTYLQFEG PPPICEVHCP
TNELLTDSTG VILSQSYPGS YPQFQTCSWL VRVEPEYNIT ITVEYFLSEK QYDEFEIFDG
PSGQSPLLKA LSGNYSAPLV VTSSSNSVYL RWSSDHAYNR KGFKIRYSAP YCSLPRAPLH
GFILGQTSSQ PGGSIHFGCN AGYRLVGHSM AICTRHPQGY HLWSEAIPLC QALSCGLPEA
PKNGMVFGKE YTVGTKAVYS CSEGYHLQEG AEATAECLDT GLWSNRNVPP KCVPVACPDV
SSIGVEHGRW RLIFETQYQF QAQLMLVCDP GYYYTGQRVI RCQANGKWSL GDSMPTCQII
SCGELPLPPN GHRIGTLSVY GATAIFSCNS GYTLVGSRVR ECMANGLWSG SEVRCLGDCT
SFFCKLVFDS LSSPCPTKAG HCGTPEPIVN GHINGENYSY RGSVVYQCNA GFRLIGMSVR
ICQQDHHWSG KTPFCVPITC GHPGNPINGL TQGNQFNLND VVKFVCNPGY VAEGAARSQC
LANGQWSDTL PTCRIINCTD PGHQENSVRQ VHASGPHRFS YGTTVSFQCN HGFYLLGTPV
LSCQGDGTWD RPRPQCLLVS CGHPGSPPHS QMSGDSFTVG AVVRYSCAGK RTLVGNATRM
CGLDGHWTGS LPHCSGTSMG VCGDPGIPAH GIRLGDSFDP GSLMRFSCEA GHVLRGSSER
TCLANGSWSG SQPECGVISC GNPGTPSNAR VVFSDGLVFS SSIVYECREG YYATGLLSRH
CSVNGTWTGS DPECIVINCG DPGIPANGLR LGNDFRYNKT VTYQCVPGYM MESHRVSVLS
CTKDRTWNGT KPVCKAIMCM PPQLIPNGKV VGSDFTWGSS VTYACLEGYQ LSLPAVLTCE
GNGSWTGELP QCFPVFCGDP GVPAHGRRED RGFSYRSSVS YSCHPPLVLV GSPRRFCQSD
GTWSGTQPSC IDPTLTMCAD PGVPQFGIQN NSQGYQVGST VLFRCQKGYL LQGSTTRTCL
PNLTWSGTPP DCVPHHCRQP ETPTHAHVGA LDLPSMGYTL IYSCQEGFSL KGGSEHRTCK
ADGSWTGKPP ICLEVRPSGR PVNTAREPPL TQASIPGDVF AKNSLWKGAY EYQGKKQPAM
LRVTGFQVAN SKVNATMIDH SGVELHLAGI YKKEDFHLLL QVYQITGPAE IFVNKFKDDH
WALDGHVSAE SSGGTFIYQG SVKGQGFGQF GFQRLDLRLL ESDPESIGRH FASNSSSVAA
AILVPFIALI IAGFVLYLYK HRRRPKVPFN GYAGHENTNV RATFENPMYD RNIQPTDIMA
SEAEFTVSTV CTAV
//
