ID   A0A2K6GLM7_PROCO        Unreviewed;       366 AA.
AC   A0A2K6GLM7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=Transmembrane protein 25 {ECO:0000313|Ensembl:ENSPCOP00000027150.1};
GN   Name=TMEM25 {ECO:0000313|Ensembl:ENSPCOP00000027150.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000027150.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000027150.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6GLM7; -.
DR   STRING; 379532.ENSPCOP00000027150; -.
DR   Ensembl; ENSPCOT00000037951.1; ENSPCOP00000027150.1; ENSPCOG00000026021.1.
DR   GeneTree; ENSGT01080000257333; -.
DR   OMA; CVCLGRW; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090394; P:negative regulation of excitatory postsynaptic potential; IEA:Ensembl.
DR   GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR042864; TMEM25.
DR   PANTHER; PTHR47224; TRANSMEMBRANE PROTEIN 25; 1.
DR   PANTHER; PTHR47224:SF1; TRANSMEMBRANE PROTEIN 25; 1.
DR   Pfam; PF08205; C2-set_2; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..366
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014389426"
FT   TRANSMEM        235..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          30..123
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          298..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   366 AA;  39061 MW;  F902B1F1D0A94642 CRC64;
     MALPLGPATL SHTLLFLPAL LSSGWGELAP QIDGQTWAEL ALRENERHAF TCRVAGGPGT
     PRLAWYLDGQ LQEASTSRLL SVGGEAFSGG TSTFTITAQR AQHELNCSLQ DPGSGQSANA
     SVILNVQFKP EIAQVGAKYQ EAQGPGLLVV LFALVRANPP ANVTWIDQDG PVTVNTSDFL
     VLDAQNYPWL TNHTVQLQLH SLAHNLSVVA TNDVGVTSAS LPAPGLLATR VEVPLLGIVV
     AGGLALGTLV GFSTLVACLV CRKEKTTKGP SRRPSLVSSD SNNLKLNNVR LPRENMSLPS
     NLQLNDLTPD SRAGKSADRQ IPRNNSRPEL LDPEPGGLLT SRGFIRLPML GYIYRVSSVS
     SDEIWL
//