ID A0A2K6GLY8_PROCO Unreviewed; 2907 AA.
AC A0A2K6GLY8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Collagen type XII alpha 1 chain {ECO:0000313|Ensembl:ENSPCOP00000027260.1};
GN Name=COL12A1 {ECO:0000313|Ensembl:ENSPCOP00000027260.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000027260.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000027260.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 379532.ENSPCOP00000027260; -.
DR Ensembl; ENSPCOT00000038065.1; ENSPCOP00000027260.1; ENSPCOG00000026081.1.
DR GeneTree; ENSGT00940000154923; -.
DR OMA; WKRPPDE; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0035987; P:endodermal cell differentiation; IEA:Ensembl.
DR CDD; cd00063; FN3; 17.
DR CDD; cd01482; vWA_collagen_alphaI-XII-like; 4.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 17.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 4.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF70; PH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 4.
DR Pfam; PF00041; fn3; 17.
DR Pfam; PF00092; VWA; 4.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00060; FN3; 17.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00327; VWA; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 12.
DR SUPFAM; SSF53300; vWA-like; 4.
DR PROSITE; PS50853; FN3; 16.
DR PROSITE; PS50234; VWFA; 4.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..2907
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014346497"
FT DOMAIN 27..117
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 140..316
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 336..426
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 440..616
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 634..723
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 725..816
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 817..905
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 907..998
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1000..1090
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1110..1282
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1298..1387
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1388..1478
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1479..1569
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1570..1664
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1667..1761
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1848..1938
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1939..2029
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2030..2118
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2119..2206
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2235..2408
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 984..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2611..2740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2775..2907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2640..2659
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2686..2703
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2784..2798
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2862..2880
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2892..2907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2907 AA; 315735 MW; B12FE70BD8840154 CRC64;
MRTRLPPALA ALGAALLLSS IEAEVDPPSD LNFKIIDENT VHMSWARPVD PILGYRITVD
PTTDGPTKEF TLAASTTETL LSDLIPEIEY VVTITSYNEV EESVPVIGQL TIQTGVSTKP
GEKKPGKTEM QKCSVSAWTD LVFLVDGSWS VGRNNFKYIL DFIAALVSAF DIGEEKTRVG
VVQYSSDTRT EFNLNQYYQR DELLAAIKKI PYKGGNTMTG DAIDYLVKNT FTDSAGARVG
FPKVAIIITD GKSQDEVEIP ARELRNVGVE VFSLGIKAAD AKELKQIAST PSLSHVFNVA
NFDAIVDIQN EIISQVCSGV DEQLGELVSG EEIVEPPSNL IAMEVSSKYI KLNWNPSPSP
VTGYKVVLTP MTAGRRQHAL SVGPQTTMLS VRDLSADTEY QISVYAMKGL TSSEPVSVME
KTQPMKVQVE CSRGVDIKAD IVFLVDGSYS IGIANFVKVR AFLEVLVKSF EISPNRVQIS
LVQYSRDPHT EFSLKKFNKV EDIIEAINTF PYRGGSTNTG KAMTYVREKI FVPSKGSRSN
VPKVMILITD GKSSDAFRDP AIKLRNSDVE IFAVGVKDAV RSELEAIASP PAETHVFTVE
DFDAFQRISF ELTQSICLRI EQELAAIKKK AYVPPKNLSF SEVTSYSIKA NWSPAGENVF
SYHITYKEAA GEDEVTVVEP ASSTSVVLNN LKPETLYLVN VTAEYEDGFS IPLAGEETTA
EVKGAPRNLK VTDETTDSFK ITWTQAPGRV LRYRIIYRPV AGGESKEVTT PANQRRRTLE
NLTPDTKYEV SVIPEYFSGP GSPLTGNAAT EEVRGNPRNL RVSDPTTSTM KLSWSGAPGK
VKQYLVTYTP VAGGETQEVT VGGDTTTTVL RELKEGTRYA LSVTALYSSG AGDALSGEGT
TLEERGSPQD LVIKDITDTS VGAYWTSAPG MVRGYRVSWK SLYDDVEAGE KNLPEDAIHT
MIENLQPETK YKISIFATYS SGEGEPLTGD ATTESSRFKS PRNLKTSDPT MSSFRVTWEP
APGEVKGYKV TFHPTGDDRR LGELVVGPYD NTVVLEELRA GTTYKVNVFG MFDGGESSPL
VGQEMTTLSD TTVMPILSSG MECLTRAEAD IVLLVDGSWS IGRANFRTVR SFISRIVEVF
EIGPKRVQIA LAQYSGDPRT EWQLNAHRDK NSLLQAVANL PYKGGNTLTG MALNFIRQQS
FRTQAGMRPR ARKIGVLITD GKSQDDVEAP SKKLKDEGVE LFAIGIKNAD EVELKMIATD
PDDTHAYNVA DFESLSRIVD DLTINLCNSV KGPGDLEAPS NLVISERTHR SFRVSWVPPS
DNVDRYKVEY YPVSGGKRQE FYVSRLDTST VLKDLKPETE YVVNVYSVVE DEYSEPLKGT
EKTLPVPVVS LNIYDVSPTT MHVQWQPVGG ATGYILSYEP TQVAELTKPK EMRVGPTVND
VELTDLSPNT EYAVTVQAAL HDLTSEPVTA RQVTLPLPRP QDLKLRDVTH STMNVFWEPV
PGKVRKYVVQ YKTPEEDVKE VDVDRSETSI SLKDLLSQTQ YTVSVSAVYD EGESPPVTAQ
ETTRPVPAPT NLRITDVTPQ SFRGTWDHGA SDVSLYRITW APFGSADKME TILNGDENTL
VFENLNPNTL YEVSVTAIYP DESESDDLTG SERTLRLITI TPAPKSGPRN LQVYNATSNS
LTVKWDPASG RVQKYRVIYQ PSSGEGNEQT TTIGGRQNSV VLQKLRPDTP YTITVSSLYP
DGEGGRMTGR GKTKPLNTVK NLRVYDPSTS TLNVRWDHAE GNPRQYKLFY APTAGGPEEL
VPIPGNTNYA ILRNLQPDTP YTVTVVPVYT EGDGGRTSDT GRTLVRGLAR NVQVYNPTPN
SLDVRWDPAP GPVQQYSIVY SPVAGTRPSD SIVVPGNTRT VHLERLIPDT LYSVDIVAVY
SDGPGNPSPA QGRTLPRSGP RNLRVSGETT NSLSVAWDHA DGPVHQYRII YSPTVGDPID
EYTTVPGRRN NVILQPLQSD TPYKITVIAV YEDGDGGHLT GSGRTVGLLP PQNIHISDEW
YTRFRVSWDP SPSPVLGYKI VYKPEGSNEP MEVFVGEVTS YTLHNLNPST TYDVNVYAQY
DSGLSVPLTD QGTTLYLNVT DLKTYQIGWD TFCVRWSAHR AATSYRLKLS PADGTRGQEI
TVRGSETSHC FTGLSPDTDY GVTVFVQTPN LEGPGVLVKE RTTVKPTEAP TEPPTPPPPP
TIPPARDVCK GAKADIVFLT DASWSIGDDN FNKVVKFIFN TVGGFDEISP AGIQVSFVQY
SDEVKSEFKL NTYNDKALAL GALQNIRYRG GNTRTGKALT FIKEKVLTWE SGMRKNVPKV
LVVVTDGRSQ DEVKKAALVI QQSGFSVFVV GVADVDYNEL ANIASKPSER HVFIVDDFES
FEKIEDNLIT FVCETATSSC PLIYLDGYTS PGFKMLEAYN LTEKNFASVQ GVSLESGSFP
SYSAYRLQKN AFVNQPTADL HPNGLPSSYT IILLFRLLPE TPSEPFAIWQ ITDRDYKPQV
GVIADPSSKT LSFFNKDTRG EVQTVTFDTD EVQTLFYGSF HKFQIQSFDI VCSPVWTSRD
RCCDIPSRRD EAKCPALPNA CTCTQDSIGP PGPPGPAGGP GAKGPRGERG ISGAIGPPGP
RGDSGPPGPQ GPPGPQGPNG LSIPGEQGRQ GMKGDAGEPG LPGRTGTPGL PGPPGPMGPP
GDRGSPGSPG VTGPSGKPGK PGDHGRPGPS GLKGEKGDRG DIASQNMMRA VARQVCEQLI
SGQMNRFNQM LNQIPNDYHS SRNQPGPPGP PGPPGSAGTR GEPGPGGRPG FPGTPGMQGP
PGERGLPGEK GERGIGSPGP RGLPGPPGPQ GESRTGPPGS TGSRGPPGPP GRPGNSGIRG
PPGPPGYCDS SQCASIPYNG QGYPGSG
//
