ID A0A2K6GM78_PROCO Unreviewed; 490 AA.
AC A0A2K6GM78;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=NF-kappa-B essential modulator {ECO:0000256|ARBA:ARBA00040893};
DE AltName: Full=IkB kinase-associated protein 1 {ECO:0000256|ARBA:ARBA00041660};
DE AltName: Full=Inhibitor of nuclear factor kappa-B kinase subunit gamma {ECO:0000256|ARBA:ARBA00043239};
DE AltName: Full=NF-kappa-B essential modifier {ECO:0000256|ARBA:ARBA00041525};
GN Name=IKBKG {ECO:0000313|Ensembl:ENSPCOP00000027319.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000027319.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000027319.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A2K6GM78; -.
DR STRING; 379532.ENSPCOP00000027319; -.
DR Ensembl; ENSPCOT00000038128.1; ENSPCOP00000027319.1; ENSPCOG00000026138.1.
DR GeneTree; ENSGT00530000063808; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0008385; C:IkappaB kinase complex; IEA:Ensembl.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0000151; C:ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:Ensembl.
DR GO; GO:1990450; F:linear polyubiquitin binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR GO; GO:0051650; P:establishment of vesicle localization; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0050862; P:positive regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR CDD; cd09803; UBAN; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 2.
DR Gene3D; 1.20.5.990; Nemo cc2-lz domain - 1d5 darpin complex; 1.
DR InterPro; IPR032419; CC2-LZ_dom.
DR InterPro; IPR021063; NEMO_N.
DR InterPro; IPR034735; NEMO_ZF.
DR PANTHER; PTHR31553; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR PANTHER; PTHR31553:SF3; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR Pfam; PF16516; CC2-LZ; 1.
DR Pfam; PF11577; NEMO; 1.
DR Pfam; PF18414; zf_C2H2_10; 1.
DR PROSITE; PS51801; ZF_CCHC_NOA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01142}.
FT DOMAIN 460..490
FT /note="CCHC NOA-type"
FT /evidence="ECO:0000259|PROSITE:PS51801"
FT REGION 439..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 123..425
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 490 AA; 56321 MW; AC8B6FFB4F23C741 CRC64;
MALMAQVGKL RPKQTPSPIL IPKFPVWGEE TLPSLADVLS GRRRCCSRSK APSLTLVYKA
RTFWNGTTVT CWMSRHLWKN QLCEMVQPSG GPAGDQDVLC EESSLGKPAM LHLPSEQGSS
ETLQRCLEEN QELRDAIRQS NQMLRERCEE LLHFQVSQRE EKEFLMDKFQ EAKKLVERLS
LEKLDLRRQR EQALQEVEHL KRCQQQMAED KASVKAQVTS LLGELQESQS CLEAATKERQ
ALEGRARAAS EQARQLESEC EALQQQHSVQ VDQLRMQNQS VEAALRMERQ AASEEKRKLA
QLQVAYHQLF QEYDNHIKSS GVSSERKRGI QLEDLKQRLQ QAEEALVAKQ EVIDKLKEEA
EQHKIVMETV PVLKAQADIY KADFQAERQA REKLAEKKEL LQEQLEQLQR EYSKLKASCQ
ESARIEDMRK RHIEVSQAPL PPAPAHSFHL ALPSQRRSPP EEPPDFCCPK CQYQAPDMDT
LQIHVMECIE
//