ID A0A2K6GNF4_PROCO Unreviewed; 1911 AA.
AC A0A2K6GNF4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Receptor-type tyrosine-protein phosphatase F {ECO:0000256|ARBA:ARBA00044158};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRF {ECO:0000313|Ensembl:ENSPCOP00000027749.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000027749.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000027749.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR STRING; 379532.ENSPCOP00000027749; -.
DR Ensembl; ENSPCOT00000038601.1; ENSPCOP00000027749.1; ENSPCOG00000026423.1.
DR GeneTree; ENSGT00940000155060; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0050839; F:cell adhesion molecule binding; IEA:Ensembl.
DR GO; GO:0035373; F:chondroitin sulfate proteoglycan binding; IEA:Ensembl.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0031102; P:neuron projection regeneration; IEA:Ensembl.
DR GO; GO:0048679; P:regulation of axon regeneration; IEA:Ensembl.
DR GO; GO:0099560; P:synaptic membrane adhesion; IEA:Ensembl.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14629; R-PTP-F-2; 1.
DR CDD; cd14626; R-PTPc-F-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1911
FT /note="Receptor-type tyrosine-protein phosphatase F"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014460127"
FT TRANSMEM 1265..1288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..123
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 135..229
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 237..319
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 326..416
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 421..515
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 519..609
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 614..711
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 716..824
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 825..918
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 923..1015
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1356..1611
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1531..1602
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1643..1902
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1820..1893
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 187..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1911 AA; 212784 MW; DC3780EF777CC33C CRC64;
MAPEPAPGRM MVPLVPALVM LGLVAGAHGD SKPAFIKVPE DQTGLSGGVA SFVCQATGEP
KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA
KLSVLEEEQL PPGFPSIDMG PQLKVVEKAR TATMLCAAGG NPDPEISWFK DFLPVDPATS
NGRIKQLRSG GSPIRGKNIE SSEESDQGKY ECVATNSAGT RYSAPANLYV RVRRVAPRFS
IPPSSQEVMP GGSVNLTCVA VGAPMPYVKW MMGAEELTKE DEMPVGRNVL ELSNVMRSAN
YTCVAISSLG MIEATAQVTV KALPKPPIDL VVTETTATSV TLTWDSGNSE PVSYYGIQYR
AAGTEGPFQE VDGVATTRYS IGGLSPFSEY AFRVLAVNSI GRGPPSEAVR ARTGEQAPSS
PPRRVQARML SASTMLVQWE PPEEPNGLVR GYRVYYTPDS RRPLSAWHKH NTDAGLLTTV
GSLLPGITYS LRVLAFTAVG DGPPSPTIQV KTQQGVPAQP ADFQAEAESD TRIQLSWLLP
PQERIIKYEL VYWAAEDEGQ QHKVTFDPTS SYTLEDLKPD TLYHFQLAAR SDLGVGVFTP
TIEARTAQST PSAPPQKVTC VSAGSTTVRV SWVPPPADSR NGVITQYSVA YEAVDGEDRV
RHVVDGISRE HSSWDLVGLE KWTEYRVWVR AHTDVGPGPE SSPVLVRTDE DVPSGPPRKV
EVEPLNSTAV HVSWKLPVPS KQHGQIRGYQ VTYVRLENGE PRGPPVIQDV MLAEAQWRPE
ESEDYETTIS GLTPETTYSV TVAAYTTKGD GARSKPKIVT TTGAVPGQPT MMVSTTAMNT
ALLQWHPPKE LPGELLGYRL QYRRADEARP NTIDFGKDDQ HFTVTGLHKG ATYIFRLAAK
NRAGPGKEFE KEITTPEDLP SGFPQNLHVT GLTTSTTELA WDPPVLAERN GRITNYTVVF
RDINSQQELQ NITVDTRLTL SGLKPDTTYD IKVRAWTSKG AGPLSPSIQS RTMPVEQVFA
KNFRVAAAMK TSVLLSWEVP DSYKSAVPFK ILYNGQSVEV DGHSMRKLIA DLQPNTEYSF
VLMNRGSSAG GLQHLVSIRT APDLLPHKPM PASAYIEDGR FSLSMPHVQD PSLVRWFYIV
VVPIDRVGGS MLAPRWSTPE ELELDELLEA IEQGGTERRR RRQTERLKPY VAAQVDVLPE
TFTLGDKKSY RGFYNRPLSP DLSYQCFVLA SLKEPVDQKR YASSPYSDEI VVQVTPAQQQ
EEPEMLWVTG PVLAVILIIL IVIAILLFKR KRTHSPSSKD EQSIGLKDSL LAHSSDPVEM
RRLNYQTPGM RDHPPIPITD LADNIERLKA NDGLKFSQEY ESIDPGQQFT WENSNLEVNK
PKNRYANVIA YDHSRVILTS IDGVPGSDYI NANYIDGYRK QNAYIATQGP LPETMGDFWR
MVWEQRTATV VMMTRLEEKS RVKCDQYWPA RGTETYGLIQ VTLLDTVELA TYTVRTFALH
KSGSSEKREL RQFQFMAWPD HGVPEYPTPI LAFLRRVKAC NPLDAGPMVV HCSAGVGRTG
CFIVIDAMLE RMKHEKTVDI YGHVTCMRSQ RNYMVQTEDQ YVFIHEALLE AATCGHTEVP
ARNLYAHIQK LGQVPPGESV TAMELEFKLL ASSKAHTSRF ISANLPCNKF KNRLVNIMPY
ELTRVCLQPI RGVEGSDYIN ASFLDGYRQQ KAYIATQGPL AESTEDFWRM LWEHNSTIIV
MLTKLREMGR EKCHQYWPAE RSARYQYFVV DPMAEYNMPQ YILREFKVTD ARDGQSRTIR
QFQFTDWPEQ GVPKTGEGFI DFIGQVHKTK EQFGQDGPIT VHCSAGVGRT GVFITLSIVL
ERMRYEGVVD MFQTVKTLRT QRPAMVQTED QYQLCYRAAL EYLGSFDHYA T
//