ID A0A2K6GNU2_PROCO Unreviewed; 842 AA.
AC A0A2K6GNU2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Very low density lipoprotein receptor {ECO:0000313|Ensembl:ENSPCOP00000027910.1};
GN Name=VLDLR {ECO:0000313|Ensembl:ENSPCOP00000027910.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000027910.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000027910.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6GNU2; -.
DR Ensembl; ENSPCOT00000038769.1; ENSPCOP00000027910.1; ENSPCOG00000026506.1.
DR GeneTree; ENSGT00940000155460; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 8.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 767..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 381..416
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 466..509
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 510..552
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 553..596
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 597..641
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 18..30
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 25..43
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 37..52
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 57..69
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 64..82
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 119..134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 139..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 146..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 158..173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 178..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 185..203
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 224..236
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 231..249
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 243..258
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 263..275
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 270..288
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 282..297
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 311..329
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 385..395
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 842 AA; 93062 MW; 4007637B25C9907C CRC64;
FGYLSPHPSL ITRRKAKCEA SQFQCTNGRC ITLLWKCDGD EDCVDGSDEK NCVKKTCAES
DFVCNNGQCV PNRWQCDGDP DCEDGSDESP EQCHMRTCRI NEISCGARST QCIPVSWRCD
GENDCDSGED EENCGNITCS PDEFTCSSGR CISKNFVCNG QDDCNDGSDE LDCAPPTCGA
HEFQCSTSSC IPISWVCDDD ADCSDQSDES LEQCGRQPVI HTKCPASEIQ CGSGECIHKK
WRCDGDPDCK DGSDEVNCPS RTCRPDQFEC EDGSCIHGSR QCNGIRDCVD GSDEVNCKNV
NQCLGPGKFK CRSGECIDIS KVCNQEQDCR DWSDEPLKEC HVNECLVNNG GCSHICKDLV
IGYECDCAAG FELIDRKTCG DIDECQNPGI CSQICINLKG GYKCECSRGY QMDLATGVCK
AVGKEPSLIF TNRRDIRKIG LERKEYIQLV EQLRNTVALD ADIAAQKLFW ADLSQKAIFS
ASIDDKVGRH VKMIDNVYNP AAIAVDWVYK TIYWTDAASK TISVATLDGT KRKSLFNSDL
REPASIAVDP LSGFVYWSDW GEPAKIEKAG MNGFDRRPLV TVDIQWPNGI TLDLIKSRLY
WLDSKLHMLS SVDLNGQDRR IVLKSLEFLA HPLALTIFED RVYWIDGENE AVYGANKFTG
SELATLVNNL NDAQDIIVYH ELIQPSGKNW CEEDMENGGC EYLCLPAPQI NDHSPKYTCS
CPNGYNLKEN GRECQSKSVS DPFISSAGIN VTTAVSEVSV PPKGTSAAWA ILPLLLLVMA
AVGGYLMWRN WQHKNMKSMN FDNPVYLKTT EEDLSIDIGR HSASVGHTYP AISVVSTDDD
LA
//