ID   A0A2K6GP00_PROCO        Unreviewed;       625 AA.
AC   A0A2K6GP00;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=TIAM Rac1 associated GEF 1 {ECO:0000313|Ensembl:ENSPCOP00000027971.1};
GN   Name=TIAM1 {ECO:0000313|Ensembl:ENSPCOP00000027971.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000027971.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000027971.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6GP00; -.
DR   Ensembl; ENSPCOT00000038834.1; ENSPCOP00000027971.1; ENSPCOG00000026538.1.
DR   GeneTree; ENSGT00940000156294; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd01255; PH2_Tiam1_2; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR   PANTHER; PTHR46001:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM1; 1.
DR   PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT   DOMAIN          73..267
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          44..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          489..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   625 AA;  71044 MW;  EBE70DB3653A239D CRC64;
     MMSALWKIKR KPRIENNDKS SDSIYRTLHL STEQVAAFCR SLHEMNPSDQ SPSPQDSTGP
     QLATMRQLSD ADKLRKVICE LLETERTYVK DLNCLMERYL KPLQKETFLT QDELDVLFGN
     LTEMVEFQVE FLKTLEDGVR LVPDLEKLEK VDQFKKVLFS LGGSFLYYAD RFKLYSAFCA
     SHTKVPKVLV KARTDAAFKA FLDAQNPKQQ HSSTLESYLI KPIQRILKYP LLLKELFALT
     DAESEEHYHL DVAIKTMNKV ASHINEMQKI HEEFGAVFDQ LIAEQTGEKK EVADLSMGDL
     LLHSTVIWLN PPASLGKWKK EPELAAFVFK TAVVLVYKDG SKQKKKLVGS HRLSIYEDWD
     PFRFRHMIPT EALQVRALAS ADAEANAVCE IVHVKSESEG RPERVFHLCC SSPESRKDFL
     KAVHSILRDK HRRQLLKTES LPSSQQYVPF GGKRLCALKG ARPAMSRAVS APSKSLGRRR
     RRLARNRFTI DSDAVSASSP EKESQEPPGG GDTDRWVEEQ FDLAQYEEQD DIKETDILSD
     DDEFCESVKG ASVDTELQER LQAASISQRE RGRKTLDSHA SRMTQLKKQA ALSGGINGGL
     ESTSEEVIWV RREDFAPTRK LNTEI
//