ID   A0A2K6GPT5_PROCO        Unreviewed;       840 AA.
AC   A0A2K6GPT5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO1 {ECO:0000313|Ensembl:ENSPCOP00000028251.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000028251.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000028251.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A2K6GPT5; -.
DR   Ensembl; ENSPCOT00000039136.1; ENSPCOP00000028251.1; ENSPCOG00000026720.1.
DR   GeneTree; ENSGT00940000157182; -.
DR   OMA; WKQRVRT; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:UniProt.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF13; ANOCTAMIN-1; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        215..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        292..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        370..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        416..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        460..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        586..609
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          3..201
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          204..780
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          809..829
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   840 AA;  97747 MW;  3BCD5A00DFE0E224 CRC64;
     MDYHEDDKQF RRDEYEGNLL EAGLELERDE DTKIHGLGFV KIHAPWNVLC REAEFLKLKM
     PTKKMYRINE TRGLLKKINS VLQKITDPIQ PRVAEHRPQT MKRLSYPFSR EKQHLFDLSD
     KDSFFDSKTR STIVYEILKR TTCTKAKYSM GITSLLANGV YSAAYPLHDG DYEGENVEFN
     DRKLLYEEWA RYGVFYKYQP IDLIRKYFGE KIGLYFAWLG VYTQMLIPAS VVGIIVFLYG
     CATVDENIPS MEMCDQRHNI TMCPLCDKTC SYWKMSSACA TARASHLFDN PATVFFSVFM
     ALWAATFMEH WKRKQMRLNY LWDLTGFEEE EDHPRAEYEA RVLEKSLRKE SRNKETDKVK
     LTWRDRFPAY FTNLVSIVFM IAVTFAIVLG VIIYRISTAA ALAMNSSPSV RSNIRVTVTA
     TAVVINLVVI ILLDEVYGCI ARWLTKIEVP KTEKSFEERL IFKAFLLKFV NSYTPIFYVA
     FFKGRFVGRP GDYVYIFRSF RMEECAPGGC LMELCIQLSI IMLGKQLIQN NLFEIGIPKM
     KKLIRHLKLK RQRPPEHEEH VKRKQRYEVD YNLEPFAGLT PEYMEMIIQF GFVTLFVASF
     PLAPLFALLN NIIEIRLDAK KFVTELRRPV AVRAKDIGIW YNILRGVGKL AVIINAFVIS
     FTSDFIPRLV YLYMYSQNGT MHGFVNHTLS SFNVSDFQNG TAPNDPLDLG YEVQICRYKD
     YREPPWSEHK YDISKDFWAV LAARLAFVIV FQNLVMFMSD FVDWVIPDIP KDISQQIHKE
     KVLMVELFMR EEQGKLQLLD TWMERERKKD EPCNNHNARA CPDSLGSGPA PDHAYHGGVL
//