ID A0A2K6GQ63_PROCO Unreviewed; 456 AA.
AC A0A2K6GQ63;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Solute carrier family 29 member 1 (Augustine blood group) {ECO:0000313|Ensembl:ENSPCOP00000028391.1};
GN Name=SLC29A1 {ECO:0000313|Ensembl:ENSPCOP00000028391.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000028391.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000028391.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR AlphaFoldDB; A0A2K6GQ63; -.
DR STRING; 379532.ENSPCOP00000028391; -.
DR Ensembl; ENSPCOT00000039292.1; ENSPCOP00000028391.1; ENSPCOG00000026818.1.
DR GeneTree; ENSGT00950000182898; -.
DR OMA; KIMFINS; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015207; F:adenine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015212; F:cytidine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015208; F:guanine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0005326; F:neurotransmitter transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015211; F:purine nucleoside transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015389; F:pyrimidine- and adenosine-specific:sodium symporter activity; IEA:Ensembl.
DR GO; GO:0015210; F:uracil transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015213; F:uridine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0032238; P:adenosine transport; IEA:Ensembl.
DR GO; GO:0035344; P:hypoxanthine transport; IEA:Ensembl.
DR GO; GO:0035340; P:inosine transport; IEA:Ensembl.
DR GO; GO:0001504; P:neurotransmitter uptake; IEA:Ensembl.
DR GO; GO:0035364; P:thymine transport; IEA:Ensembl.
DR InterPro; IPR034764; ENT1/ENT2.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00939; 2a57; 1.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF9; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR PIRSF; PIRSF016379; ENT; 1.
DR PRINTS; PR01130; DERENTRNSPRT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 254..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 49938 MW; 221909A52A54C876 CRC64;
MTTSHQPQDR YKAVWLIFFM LGLGTLLPWN FFMTATQYFT NRLDMSQNVS LVTARLSKDI
QASAAPTTAS PARNSLSALF NNVMTICAML PLLLFTCLNS FLHQRISQSV RILGSLVAIL
LVFLITAILV KVQLDALPFF VITMVKIMLI NSFGAILQGS LFGLAGLLPA SYTAPIMSGQ
GLAGFFTSVA MICAIASGSE LSESAFGYFI TACVVIILTI ICYLGLPRLE FYRYYQQLKL
EGPGEQETKL DLISKGEEPR AGKEESGVSA SNSGPTNNSH CIRAILKNIS VLAFSVCFIF
TITIGMFPAV VVEVKSSIAG TSAWGKYFIA VSCFLTFNIF DWLGRSLTAV LMWPGKDSRW
LPGLVLARVV FVPLLLLCNV QPRRYLAVVF EHDAWFIFFM AAFAFSNGYL ASLCMCFGPK
KVKPAEAETA GTIMAFFLCL GLALGAVFSF LFRAIV
//
