ID A0A2K6GQU3_PROCO Unreviewed; 1221 AA.
AC A0A2K6GQU3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=ATP binding cassette subfamily B member 4 {ECO:0000313|Ensembl:ENSPCOP00000028626.1};
GN Name=ABCB4 {ECO:0000313|Ensembl:ENSPCOP00000028626.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000028626.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000028626.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily.
CC {ECO:0000256|ARBA:ARBA00007577}.
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DR AlphaFoldDB; A0A2K6GQU3; -.
DR Ensembl; ENSPCOT00000039553.1; ENSPCOP00000028626.1; ENSPCOG00000026964.1.
DR GeneTree; ENSGT00940000159418; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 2.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR43394:SF11; ALPHA-FACTOR-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR43394; ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 800..822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 895..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..308
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 343..579
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 661..948
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 983..1214
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1221 AA; 134682 MW; 8187C324B20D7DA6 CRC64;
MDLEAARNGT ARNLRRAEGG FELRSKKFHS TVNLFKMFLF CFYLVNFSLS LLNPGRILEE
EMTRYAYYYS GLGAGVLVAA YIQVSFWTLA AGRQIRKIRQ KFFHAILRQE IGWFDINDIT
ELNTRLTDDI SKISEGIGDK VGMFFQAVAT FFSGFIVGFI RGWKLTLVIM AISPILGLSA
AIWAKILSTF SDKELAAYAK AGAVAEEALG AIKTVIAFGG QNKELERYQK HLENAKKIGI
KKAISANISM GISFLFIYAS YALAFWYGST LVIAKEYTIG NAMTVFFSIL IGAFSVGQAA
PCIDAFANAR GAAYVIFDII DNNPKIDGFS ERGHKPDSIK GNLEFNDVHF SYPSRANVKI
LKGLNLKVQS GQTVALVGRS GCGKSTMVQL IQRLYDPDEG TVNIDGQDIR TFNVRYLREI
IGVVSQEPVL FSTTIAENIR YGRGNVTMDE IKKAVKAANA YEFIMNLPQK FDTLVGERGA
QLSSGQKQRI AIARALVRNP KILLLDEATS ALDTESEAEV QAALDKAREG RTTIVIAHRL
STVRNADVIA GVEDGVIVEQ GSHGELMKKE GVYYKLVNMQ TSGNQIQSEE FELNDEKAAT
GMTPNGWKSR TFRNSTRKSL RNSRMYQNGF KVETNELDEN VPPVSFLKVL KLNKTEWPYF
VVGTVCAIAN GGLQPAFSVI FSEIIEIFGP GDDAVKQQKC NMFSLLFLGL GIISFFTFFL
QGFTFGKAGE ILTARLRSKA FKAMLRQDMS WFDDPANSTG ALSTRLAMDA AQVQGATGTR
LALIAQNTAN LGTGIIISFI YGWQLTLLLL SVVPIIAISG IVEMKMLAGN ARRDKKELET
AGKIATEAIE NIRTVVSLTQ ERKFESMYVE KLYGPYRNSV QKAHIYGITF SISQAFMYFS
YAGCFRFGAY LIVNGYMRFR DVILVFSAIV FGAVALGHAS SFAPDYAKAK LSAAHLFMLF
ERQPLIDSYS EEGLRPDKFE GNVTFNEVVF NYPSRPKVPV LQGLSLEVKK GQTLALVGSS
GCGKSTALQL LERFYDPLAG TVLLDGQQAK KLNLGIVSQE PILFDCSIAE NIAYGDNSRT
VSQDEIVSAA KAANIHPFIE TLPQKYETRV GDKGTQLSGG QKQRIAIARA LVRQPQILLL
DEATSALDTE SEKVVQEALD RAREGRTCIV IAHRLSTIQS ADLIVVFQNG KVKEHGTHQQ
LLAQKGIYFS MVSVQAGIQN L
//
