ID   A0A2K6GSS7_PROCO        Unreviewed;       651 AA.
AC   A0A2K6GSS7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Amiloride-sensitive sodium channel subunit gamma {ECO:0000256|ARBA:ARBA00039160};
DE   AltName: Full=Epithelial Na(+) channel subunit gamma {ECO:0000256|ARBA:ARBA00041623};
DE   AltName: Full=Gamma-NaCH {ECO:0000256|ARBA:ARBA00042229};
DE   AltName: Full=Nonvoltage-gated sodium channel 1 subunit gamma {ECO:0000256|ARBA:ARBA00043111};
DE   AltName: Full=SCNEG {ECO:0000256|ARBA:ARBA00041935};
GN   Name=SCNN1G {ECO:0000313|Ensembl:ENSPCOP00000029295.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000029295.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000029295.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. SCNN1G subfamily. {ECO:0000256|ARBA:ARBA00038067}.
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DR   AlphaFoldDB; A0A2K6GSS7; -.
DR   STRING; 379532.ENSPCOP00000029295; -.
DR   Ensembl; ENSPCOT00000040231.1; ENSPCOP00000029295.1; ENSPCOG00000027333.1.
DR   GeneTree; ENSGT00940000160352; -.
DR   OMA; SCDSRNF; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0050699; F:WW domain binding; IEA:Ensembl.
DR   GO; GO:0071468; P:cellular response to acidic pH; IEA:Ensembl.
DR   GO; GO:1904045; P:cellular response to aldosterone; IEA:Ensembl.
DR   GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0050891; P:multicellular organismal-level water homeostasis; IEA:Ensembl.
DR   GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR   Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF19; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT   TRANSMEM        54..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        538..564
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          582..631
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   651 AA;  73880 MW;  8AD2F137D0E59E29 CRC64;
     MAPGEKIKAK IKKNLPVTGP QAPTIKELMR WYCLNTNTHG CRRIVVSRGR LRRLLWIGFT
     LTAVALIFWQ CALLVFSFYT VSVSIKVHFQ KLDFPAVTIC NINPYKYSVV RPLLADLEQE
     TREAMKSLYG FSEIKSRKRR EAESWSSASD DTRPKFLRLV PLLVFDHEEK DTARDFVTGQ
     KRKVSGSIIH KASNVMQVHE SKQVVGFQLC ANDTSSCATY TFSSGVNAIQ EWYKLHYMNI
     MAQVPLEKKI NMSYSAEELL VTCFFDGVSC DARNFTLFHH PMHGNCYTFN SGDNATVLST
     SMGGSEYGLQ VILYINEEEY NPFLVSSTGA KVIIHRQDEY PFIEDVGTEI ETAMATSMGM
     HLTESFKLSE PYSQCTEDGS DVPVSNIYKA AYSLQICLHS CFQAKMVEKC GCAQYSQPLP
     PAANYCNYQQ HPNWMYCYYQ LHQAFVQEEL GCQSVCREAC SFKEWTLTTS LAQWPSVVSE
     KWLLPVLTWD QSRQINKKLN KTDLAKLLIF YKDLNQRSIM ENPANSIEML LSNFGGQLGL
     WMSCSVVCVI EIIEVFFIDF FSIIARRQWQ KAKEWWALRQ APPCPEAPPS PRGQDNPALN
     VDDDLPTFTS ALRLPPAPGA QVPGTPPPRY NTLRLERAFS TQLSDTQLPG P
//