ID A0A2K6GTA7_PROCO Unreviewed; 741 AA.
AC A0A2K6GTA7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=N-acetylated alpha-linked acidic dipeptidase like 1 {ECO:0000313|Ensembl:ENSPCOP00000029439.1};
GN Name=NAALADL1 {ECO:0000313|Ensembl:ENSPCOP00000029439.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000029439.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000029439.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR RefSeq; XP_012521043.1; XM_012665589.1.
DR AlphaFoldDB; A0A2K6GTA7; -.
DR STRING; 379532.ENSPCOP00000029439; -.
DR Ensembl; ENSPCOT00000040378.1; ENSPCOP00000029439.1; ENSPCOG00000027422.1.
DR GeneID; 105827431; -.
DR KEGG; pcoq:105827431; -.
DR CTD; 10004; -.
DR GeneTree; ENSGT01030000234598; -.
DR OMA; TEWMEEY; -.
DR OrthoDB; 2428249at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0043171; P:peptide catabolic process; IEA:Ensembl.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF50; AMINOPEPTIDASE NAALADL1; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 162..248
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 349..557
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 617..736
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 741 AA; 80080 MW; E86CD2961FE32D4B CRC64;
MQWAKGLGLG LGAAALLALG IILGHFAIPK NTPSISATQD LDLEILETVM GQLDASRIRE
NLRELSREPH LASSPRDEAL VQLLLQRWAD TTSGLDSAEA FEYEVLLSFP SQEQPNSVDV
VASAGGVLYS CLRSEENLTG EQGGPDVVPP YAAYAPPGTP QGLLVYANQG SEEDFKELQT
QGIKLEGTIA LTRYGGVGRG AKAVNAAKHG VAGVLVYTDP GDINDGLSLP NETFPNSWHL
PPSGVERGSY YEYFGDPLTP YLPANPSSFR LDLANVSGFP PIPSQPIGFQ DAKVLLCNLN
GSSAPAAWQG ALGCDYRLGP GFRPDGDFPA DSQVKVSVYN RLQLRNSSNV LGIIRGAVEP
DRYVLYGNHR DSWVHGAVDP SSGTAVLLEL SRILGTLLKK GTWRPRRSIV FASWGAEEFG
LIGSTEFTEE FFSKLQERTV AYLNVDISVF ANATLRVQGT PPVQSVVFSA AKEIPSPGPG
DLSIYDNWIR YFNRSSPVYG LVPRLGSLGA GSDYAPFIHF LGISSMDIAY TYDQSKTSAR
IYPTYHTAFD TFDYVDKFVD PGFSSHQAVA RTAGSVLLRL SDSFFLPLNV SDYSDTLRSF
LQAAQQELGA LLEQHSISLG PLVAAVEKFE AAAAALGQYI STLQQGSPDP LQVRMLNDQL
MLLERTFLNP RAFPEERYYS HVLWAPRTGS TATFPGLANA CSKARDTSPG SEAWAEVQRQ
LSIVVVALEG AAATLRPVAD L
//
