ID A0A2K6GUL4_PROCO Unreviewed; 398 AA.
AC A0A2K6GUL4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=LIM and senescent cell antigen-like-containing domain protein {ECO:0000256|PIRNR:PIRNR038003};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000029879.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000029879.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Adapter protein in a cytoplasmic complex linking beta-
CC integrins to the actin cytoskeleton, bridges the complex to cell
CC surface receptor tyrosine kinases and growth factor receptors.
CC {ECO:0000256|PIRNR:PIRNR038003}.
CC -!- SUBUNIT: Part of the heterotrimeric IPP complex composed of integrin-
CC linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
CC {ECO:0000256|PIRNR:PIRNR038003}.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|PIRNR:PIRNR038003}. Cell membrane
CC {ECO:0000256|PIRNR:PIRNR038003}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR038003}.
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DR AlphaFoldDB; A0A2K6GUL4; -.
DR STRING; 379532.ENSPCOP00000029879; -.
DR Ensembl; ENSPCOT00000040825.1; ENSPCOP00000029879.1; ENSPCOG00000027638.1.
DR GeneTree; ENSGT00940000153518; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd09331; LIM1_PINCH; 1.
DR CDD; cd09332; LIM2_PINCH; 1.
DR CDD; cd09333; LIM3_PINCH; 1.
DR CDD; cd09334; LIM4_PINCH; 1.
DR CDD; cd09335; LIM5_PINCH; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 5.
DR InterPro; IPR047944; LIMS1/2-like_LIM1.
DR InterPro; IPR047946; PINCH-1/2-like.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24210:SF11; LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 1; 1.
DR PANTHER; PTHR24210; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00412; LIM; 5.
DR PIRSF; PIRSF038003; PINCH; 1.
DR SMART; SM00132; LIM; 5.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 6.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 4: Predicted;
KW Cell junction {ECO:0000256|PIRNR:PIRNR038003};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR038003};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PIRNR:PIRNR038003};
KW Membrane {ECO:0000256|PIRNR:PIRNR038003};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 70..131
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 133..190
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 253..312
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 313..372
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 379..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 45817 MW; 8E024B07FB883BED CRC64;
MAFPGRVRPC VIPENEELPG TVLNNVHEAN GNEDERAVSK LQRRHSDIKV YKEFCDFYAK
FNMANALASA TCERCKGGFA PAEKIVNSNG ELYHEQCFVC AQCFQQFPEG LFYEFEGRKY
CEHDFQMLFA PCCHQCGEFI IGRVIKAMNN SWHPECFRCD LCQEVLADIG FVKNAGRHLC
RPCHNREKAR GLGKYICQKC HAIIDEQPLI FKNDPYHPDH FNCANCGKEL TADARELKGE
LYCLPCHDKM GVPICGACRR PIEGRVVNAM GKQWHVEHFV CAKCEKPFLG HRHYERKGLA
YCETHYNQLF GDVCFHCNRV IEGDVVSALN KAWCVNCFAC STCNTKLTLK DKFVEIDLKP
VCKHCYEKMP EEFKRRLAKR EREAKDKDKQ KKKKPVCL
//
