ID A0A2K6GW25_PROCO Unreviewed; 691 AA.
AC A0A2K6GW25;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Zinc finger protein 12 {ECO:0008006|Google:ProtNLM};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000030481.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000030481.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; A0A2K6GW25; -.
DR STRING; 379532.ENSPCOP00000030481; -.
DR Ensembl; ENSPCOT00000041429.1; ENSPCOP00000030481.1; ENSPCOG00000027965.1.
DR GeneTree; ENSGT00940000154303; -.
DR OMA; DYHCYQM; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 15.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF132; ZINC FINGER PROTEIN 939; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 15.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 10.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 7..78
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 263..290
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 291..318
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 319..346
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 347..374
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 375..402
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 403..430
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 431..458
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 459..486
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 487..514
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 515..542
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 543..570
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 571..598
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 599..626
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 627..654
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 655..677
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 691 AA; 80704 MW; A1F91816D06D1115 CRC64;
INTKLELSFK DVAVDFTQEE WQQLDPEQKI TYRDVMLENY SNLVSVGYHI IKPDVIIKLE
QGEEPWIVEG EFLLQSYPDE AWQTDDLIER VQEDEDKHSR KTVFIKRGNV PGKIFNVEMN
PVPSRKIAYK NSLCDSCEKS LTSISEYISS DGSYARMKPD ECSGCGKSLL HIKLEKIHPG
DKSYEINQNG EPYTLNEESI YQKIHILEKP FEYIECQKAF QKDPVFVNHM EEKPYKWNES
EIAFLQMSNL SVHQRSDMEM KPYECSQCGK SFCKKSKFII HQRTHTGEKP YECNQCGKSF
CQKGTLTVHQ RTHTGEKPYE CNECGKNFYQ KLHLIQHQRT HSGEKPYECS YCGKSFCQKT
HLTQHQRTHS GERPYVCHDC GKTFSQKSAL NDHQKIHTGV KLYKCSECGK CFCRKSTLTT
HLRTHTGEKP YECNECGKFF SRLSYLTVHY RTHSGEKPYE CNECGKTFYL NSALMRHQRV
HTGEKPYECN ECGKLFSQLS YLTIHHRTHS GVKPYECSEC GKTFYQNSAL CRHRRIHKGE
KPYECYICGK FFSQMSYLTI HHRIHSGEKP YECSECGKTF CQNSALNRHQ RTHTGEKAYE
CYECGKCFSQ MSYLTIHHRI HSGEKPFECN ECGKAFSRMS YLTVHYRTHS GEKPYECTEC
GKKFYHKSAF NSHQRIHRRG NVNIVDVGRL L
//
