ID   A0A2K6GW61_PROCO        Unreviewed;      1534 AA.
AC   A0A2K6GW61;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=RPTOR independent companion of MTOR complex 2 {ECO:0000313|Ensembl:ENSPCOP00000030467.1};
GN   Name=RICTOR {ECO:0000313|Ensembl:ENSPCOP00000030467.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000030467.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000030467.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RICTOR family.
CC       {ECO:0000256|ARBA:ARBA00008878}.
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DR   Ensembl; ENSPCOT00000041415.1; ENSPCOP00000030467.1; ENSPCOG00000027952.1.
DR   GeneTree; ENSGT00390000002096; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR028268; Pianissimo_fam.
DR   InterPro; IPR028267; Pianissimo_N.
DR   InterPro; IPR029453; Rictor_IV.
DR   InterPro; IPR029451; RICTOR_M.
DR   InterPro; IPR029259; RICTOR_phospho.
DR   InterPro; IPR029452; RICTOR_V.
DR   PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR   PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR   Pfam; PF14663; RasGEF_N_2; 1.
DR   Pfam; PF14666; RICTOR_M; 1.
DR   Pfam; PF14664; RICTOR_N; 1.
DR   Pfam; PF14665; RICTOR_phospho; 1.
DR   Pfam; PF14668; RICTOR_V; 1.
DR   SMART; SM01303; RasGEF_N_2; 1.
DR   SMART; SM01307; RICTOR_M; 1.
DR   SMART; SM01308; RICTOR_N; 1.
DR   SMART; SM01309; RICTOR_phospho; 1.
DR   SMART; SM01310; RICTOR_V; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT   DOMAIN          4..241
FT                   /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01308"
FT   DOMAIN          325..544
FT                   /note="Rapamycin-insensitive companion of mTOR middle"
FT                   /evidence="ECO:0000259|SMART:SM01307"
FT   DOMAIN          722..794
FT                   /note="Rapamycin-insensitive companion of mTOR"
FT                   /evidence="ECO:0000259|SMART:SM01310"
FT   REGION          824..844
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          906..936
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          996..1056
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1005..1056
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1534 AA;  172559 MW;  5AF326AEB0582BEF CRC64;
     MAAIGRGRSL KNLRIRGRND SGEENVPLDL TRCIDIQQSN EVERTQALRL VRKRILAPYT
     DFHYRHSPDT AEGQLKEDRE ARFLASKMGI IATFRSWAGI INLCKPGNSG IQSLIGVLCI
     PNMEIRRGLL EVLYDIFRLP LPVVTEEFIE ALLSVDPGRF QDSWRLSDGF VAAEAKTILP
     HRARSRPDLM DNYLALILSA FIRNGLLEGL VEVITNSDDH ISVRATILLG ELLHMANTIL
     PHSHSHHLHC LPTLMNMAAS FDIPKEKRLR ASAALNCLKR FHEMKKRGPK PYSLHLDHII
     QKAIATHQKR DQYLRVQKDI FVLKDTEEAL LMNLRDSQVL QHKENLDWNW NLIGTILKWP
     NVNLRNYKDE QLHRFVRRLL YFYKPSSKLY ANLDLDFAKS KQLTVVGCQF TEFLLESEED
     GQGYLEDLVK DIVQWLNASS GMKPERSLQN NGLLTTLSQH YFLFIGTLSC HPHGVKMLEK
     CSVFQCLLNL CSLKNQDHLL KLTVSSLDYS RDGLARVILS KILTAATDAC RLYATKHLRV
     LLRANVEFFN NWGIELLVTQ LHDKNKTISS EALDILDEAC EDKANLHALI QMKPALSHLG
     DKGLLLLLRF LSIPKGFSYL NERGYVAKQL EKWHKEYNSK YVDLIEEQLN EALTTYRKPV
     DGDNYVRRSN QRLQRPHVYL PVHLYGQLVH HKTGCHLLEV QNIITELCHN VRTPDLDKWE
     EIKKLKASLW ALGNIGSSNW GLNLLQEENV IPDILKLAKQ CEVLSIRGTC VYVLGLIAKT
     KQGCDILKCH NWDAVRHSRK HLWPVVPDDV EQLCNELSSI PSTLSLNSES TSSRHNSESE
     SAPSSMFILE DDRFGSSSTS TFFLDINEDA EPAFFDRSGP IKDKNSFPFF ASSKLVKNRI
     LNSLTLPNKK HRSSSDPKGG KLSSENKTSN RRIRTLTEPS VDFNHSDDFT PISTVQKTLQ
     LETSFVGNKH IEDIGSTPSI GENDLKFNKS FGVENHRENT SRERLVVESS TSSHMKIRSQ
     SFNTDTTTSG ISSMSSSPSR ETVGVDATTM DTDCGSMSTV VSTKTVKTSH YLTPQSNHLS
     LSKSNSVSLV PPGSSHTLPR RAQSLKAPSI ATIKSLADCN FSYTSSRDAF GYATLKRLQQ
     QRMHPSLSHS EALASPAKDV LFTDTITMKA NSFESRLTPS RIDFKKKHVG GIRSLRPTIT
     NNLVRFMKAL SYASLDKEDL LSPINQNTLQ RSSSVRSMVS SATYGGSDDY IGLALPVDIN
     DIFQVKDIPY FQTKNLPPHD DRGARVFAHD AGGLPSGTGG LVKNSFHLLR QQMSLTEIMN
     SIHSDASLFL ESTEDTGLQE HTDDNCLYCV CIEILGFQPS NQLSAICSHS DLQDIPYSDW
     CEQTIHNPLE VVPSKFSGIS GCSDGVSQEG SASSTKSTEL LLGVKTIPDD TPMCRILLRK
     EVLRLVVNLS SSVSTKCHET GLLTIKEKYP QTFDDICLYS EVSHLLSHCT FRLPCRRFIQ
     ELFQDVQFLQ MHEEAEAVLA IPPKQPIVDT SAES
//