ID   A0A2K6GWN0_PROCO        Unreviewed;       346 AA.
AC   A0A2K6GWN0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Poly(A) binding protein nuclear 1 {ECO:0000313|Ensembl:ENSPCOP00000030635.1};
GN   Name=PABPN1 {ECO:0000313|Ensembl:ENSPCOP00000030635.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000030635.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000030635.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family.
CC       {ECO:0000256|ARBA:ARBA00009458}.
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DR   AlphaFoldDB; A0A2K6GWN0; -.
DR   STRING; 379532.ENSPCOP00000030635; -.
DR   Ensembl; ENSPCOT00000041583.1; ENSPCOP00000030635.1; ENSPCOG00000028047.1.
DR   GeneTree; ENSGT00940000154606; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0042405; C:nuclear inclusion body; IEA:Ensembl.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:Ensembl.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd06845; Bcl-2_like; 1.
DR   CDD; cd12550; RRM_II_PABPN1; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 1.10.437.10; Blc2-like; 1.
DR   InterPro; IPR013280; Apop_reg_BclW.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR046371; Bcl-2_BH1-3.
DR   InterPro; IPR026298; Bcl-2_fam.
DR   InterPro; IPR002475; Bcl2-like.
DR   InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR   InterPro; IPR003093; Bcl2_BH4.
DR   InterPro; IPR020731; Bcl2_BH4_motif_CS.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR   PANTHER; PTHR11256:SF13; BCL-2-LIKE PROTEIN 2; 1.
DR   Pfam; PF00452; Bcl-2; 1.
DR   Pfam; PF02180; BH4; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PRINTS; PR01865; APOPREGBCLW.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   SMART; SM00337; BCL; 1.
DR   SMART; SM00265; BH4; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS01080; BH1; 1.
DR   PROSITE; PS01260; BH4_1; 1.
DR   PROSITE; PS50063; BH4_2; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|PROSITE-
KW   ProRule:PRU00025}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT   DOMAIN          10..27
FT                   /note="Apoptosis regulator Bcl-2 family BH4"
FT                   /evidence="ECO:0000259|PROSITE:PS50063"
FT   DOMAIN          199..276
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   COILED          146..176
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   MOTIF           10..27
FT                   /note="BH4"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00025"
SQ   SEQUENCE   346 AA;  38727 MW;  85E8D2F30C40BE8D CRC64;
     MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT
     FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG
     QVQEWMVAYL ETRLADWIHS SGGWELEAIK ARVREMEEEA EKLKELQNEV EKQMNMSPPP
     GNAGPVIMSI EEKMEADARS IYVGNVDYGA TAEELEAHFH GCGSVNRVTI LCDKFSGHPK
     GFAYIEFSDK ESVRTSLALD ESLFRGRQIK VSLCFPLYIL YSQVIPKRTN RPGISTTDRG
     FPRARYRART TNYNSSRSRF YSGFNSRPRG RVYRGRARAT SWYSPY
//