ID   A0A2K6GYM4_PROCO        Unreviewed;       442 AA.
AC   A0A2K6GYM4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=THUMP domain-containing protein {ECO:0000259|PROSITE:PS51165};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000031372.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000031372.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000256|ARBA:ARBA00008361}.
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DR   AlphaFoldDB; A0A2K6GYM4; -.
DR   STRING; 379532.ENSPCOP00000031372; -.
DR   Ensembl; ENSPCOT00000042327.1; ENSPCOP00000031372.1; ENSPCOG00000028456.1.
DR   GeneTree; ENSGT00530000063557; -.
DR   OMA; LLPVECY; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   CDD; cd11715; THUMP_AdoMetMT; 1.
DR   Gene3D; 3.30.2130.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR004114; THUMP_dom.
DR   PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR14911:SF1; THUMP DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF02926; THUMP; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   SMART; SM00981; THUMP; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF143437; THUMP domain-like; 1.
DR   PROSITE; PS51165; THUMP; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          146..252
FT                   /note="THUMP"
FT                   /evidence="ECO:0000259|PROSITE:PS51165"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   442 AA;  49757 MW;  B695D6C49A58D692 CRC64;
     MSAPPGELGP DPAPGTSAPC GRGWRPRRLN ILQERYFFTT CSDVNMLKKL KSAERLFLLI
     KKEFPLAISS VRKGKIFNEM QRLINDPGSW LNAISLWKKL LELDAKKEKL SQKDANLLKR
     KVGENEIIIA KKLKIEQLQK IEENRECQME KQIEEETLEQ RDFITKGEKF QEEEFQNDIE
     KATITHNQSS LTFRVSCRCS GTVGKAFSAQ EVGKVIGIAL MKQFGWKADL RNPNLEIFVH
     LNDIYSVVGI PVFRVPLASR TYIKTAGLRS TIAWAMASLA EIKAGAFVLD PMCGLGTILL
     EAAKECVDII ISDIPFGKKF KLGKDIKSIL QEMERVLRVG GTIVLLLSED HHRRLKDCEE
     SSIPLNSKNS YTDEPGIKRC LNLEETTGLS ETELSSFEAS NQECLEKMSP FGSLVPVECY
     KVSLGKTDAF IYKYKKSHSS AL
//