ID A0A2K6JM06_RHIBE Unreviewed; 547 AA.
AC A0A2K6JM06;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Rho guanine nucleotide exchange factor 38 {ECO:0000313|Ensembl:ENSRBIP00000000056.1};
GN Name=ARHGEF38 {ECO:0000313|Ensembl:ENSRBIP00000000056.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000000056.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000000056.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000000056.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6JM06; -.
DR STRING; 61621.ENSRBIP00000000056; -.
DR Ensembl; ENSRBIT00000000291.1; ENSRBIP00000000056.1; ENSRBIG00000000261.1.
DR GeneTree; ENSGT00950000183088; -.
DR OMA; QYTQEMV; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd07589; BAR_DNMBP; 1.
DR CDD; cd12141; SH3_DNMBP_C2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR PANTHER; PTHR22834:SF17; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 38; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 49..103
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 145..354
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 400..463
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 483..546
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 547 AA; 63105 MW; 609342BB4EAE103F CRC64;
IAQYHIPKKQ LKAEAILEPH EVSVTENYFQ TQYLIWSFSA SFRGKPNLLD MDSLMIKPIQ
RVMKYPLLLC ELRNSTPPSH PDYRALDDAF ATVKDINVNI NELKRRKDLV LKYKKNDEDE
SLKDKLSKLN IHSISKKSKR VTNHLKILTR GESQVKDNTF NREEKLFRAL EKIVRLCVKN
ISLCLQHIQD AMPLALQSVM DLQEISYNKD DEMGYSETLS NALNSCHDFA SHLQRLILTP
LSALLTLFPG PHKLIQKRYD KLLDCNSYLQ RSAGEESDLA KKEYEALNAQ LVEELQAFNQ
AARKILLNCL CSFITLIRDL MLVAQQAYST LVPVPLLVSS ISEIQNQVLE EVQNLNCVKE
NSATFIERKL SFEKKKPVQI LPEMPRQTDI HRSKLLSTYS TEELYQAKRK CNATQEYDIN
LLEGELVAVI EQKDPLGSTS RWLVDTGNVK GYVYSSFLKP YNPAKMQKVD TENRFCDDDF
ENISLFIFYA VHAFQARSDH ELSLQEYQRV HILRFCDLSG NKEWWLAEAQ GQKGYVPANY
LGKMTYA
//
