ID   A0A2K6JMR6_RHIBE        Unreviewed;       197 AA.
AC   A0A2K6JMR6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=TLE family member 5, transcriptional modulator {ECO:0000313|Ensembl:ENSRBIP00000000318.1};
GN   Name=TLE5 {ECO:0000313|Ensembl:ENSRBIP00000000318.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000000318.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000000318.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000000318.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC       {ECO:0000256|ARBA:ARBA00005969}.
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DR   AlphaFoldDB; A0A2K6JMR6; -.
DR   Ensembl; ENSRBIT00000001813.1; ENSRBIP00000000318.1; ENSRBIG00000001610.1.
DR   GeneTree; ENSGT01030000234519; -.
DR   OMA; GDTHQDD; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR005617; Groucho/TLE_N.
DR   InterPro; IPR009146; Groucho_enhance.
DR   PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR   PANTHER; PTHR10814:SF31; TRANSDUCIN-LIKE ENHANCER PROTEIN 4; 1.
DR   Pfam; PF03920; TLE_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   DOMAIN          19..131
FT                   /note="Groucho/TLE N-terminal Q-rich"
FT                   /evidence="ECO:0000259|Pfam:PF03920"
FT   REGION          174..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          27..54
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        176..197
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   197 AA;  21921 MW;  E16E792BC7920829 CRC64;
     PWHPDARHSP GSSHLPQQLK FTTSDSCDRI KDEFQLLQAQ YHSLKLECDK LASEKSEMQR
     HYVMYYEMSY GLNIEMHKQA EIVKRLNGIC AQVLPYLSQE HQQQVLGAIE RAKQVTAPEL
     NSIIRQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQAHLSKEDK
     NGHDGDTHQE DDGEKSD
//