ID A0A2K6JN39_RHIBE Unreviewed; 280 AA.
AC A0A2K6JN39;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=C1q and TNF related 1 {ECO:0000313|Ensembl:ENSRBIP00000000441.1};
GN Name=C1QTNF1 {ECO:0000313|Ensembl:ENSRBIP00000000441.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000000441.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000000441.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000000441.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017734837.1; XM_017879348.1.
DR RefSeq; XP_017734838.1; XM_017879349.1.
DR RefSeq; XP_017734839.1; XM_017879350.1.
DR STRING; 61621.ENSRBIP00000000441; -.
DR Ensembl; ENSRBIT00000002553.1; ENSRBIP00000000441.1; ENSRBIG00000002219.1.
DR Ensembl; ENSRBIT00000002565.1; ENSRBIP00000000443.1; ENSRBIG00000002219.1.
DR GeneID; 108534169; -.
DR KEGG; rbb:108534169; -.
DR CTD; 114897; -.
DR GeneTree; ENSGT00940000161333; -.
DR OMA; MGSHGQG; -.
DR OrthoDB; 5343970at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0090331; P:negative regulation of platelet aggregation; IEA:Ensembl.
DR GO; GO:2000860; P:positive regulation of aldosterone secretion; IEA:Ensembl.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0010906; P:regulation of glucose metabolic process; IEA:Ensembl.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR22923; CEREBELLIN-RELATED; 1.
DR PANTHER; PTHR22923:SF63; COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 1; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..280
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014561568"
FT DOMAIN 140..280
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 30..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 280 AA; 31571 MW; 4EA0B646BB91801C CRC64;
MGSRGQGLLL AYCLLLAFAS GPVLSRVPHV QGEQQEWEGT EELPSPPDHA KRAEEHEKYR
PSQDEGLPAS RCLRCCDPGT SMYPATAVPQ INITILKGEK GDRGDRGLQG KYGKTGSAGA
RGHTGPKGQK GSMGAPGERC KSHYAAFSVG RKKPMHSNHY YQTVIFDTEF VNLYSHFNMF
TGKFYCYVPG IYFFSLNVHT WNQKETYLHI MKNEEEVVIL FAQVGDRSIM QSQSLMLELR
EQDQVWVRLY KGERENAIFS EELDTYITFS GYLVKHATEP
//
