ID A0A2K6JP04_RHIBE Unreviewed; 99 AA.
AC A0A2K6JP04;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Apolipoprotein C-III {ECO:0000256|ARBA:ARBA00015570};
DE AltName: Full=Apolipoprotein C3 {ECO:0000256|ARBA:ARBA00031173};
GN Name=APOC3 {ECO:0000313|Ensembl:ENSRBIP00000000754.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000000754.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000000754.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000000754.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C3 family.
CC {ECO:0000256|ARBA:ARBA00011008}.
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DR RefSeq; XP_017738604.1; XM_017883115.1.
DR RefSeq; XP_017738605.1; XM_017883116.1.
DR AlphaFoldDB; A0A2K6JP04; -.
DR STRING; 61621.ENSRBIP00000000754; -.
DR Ensembl; ENSRBIT00000004311.1; ENSRBIP00000000754.1; ENSRBIG00000003998.1.
DR GeneID; 108536408; -.
DR KEGG; rbb:108536408; -.
DR CTD; 345; -.
DR GeneTree; ENSGT00390000015395; -.
DR OMA; YWSTFKG; -.
DR OrthoDB; 5265199at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
DR GO; GO:0034363; C:intermediate-density lipoprotein particle; IEA:Ensembl.
DR GO; GO:0034366; C:spherical high-density lipoprotein particle; IEA:Ensembl.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0070653; F:high-density lipoprotein particle receptor binding; IEA:Ensembl.
DR GO; GO:0055102; F:lipase inhibitor activity; IEA:Ensembl.
DR GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0034382; P:chylomicron remnant clearance; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0060621; P:negative regulation of cholesterol import; IEA:Ensembl.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Ensembl.
DR GO; GO:0010987; P:negative regulation of high-density lipoprotein particle clearance; IEA:Ensembl.
DR GO; GO:0010989; P:negative regulation of low-density lipoprotein particle clearance; IEA:Ensembl.
DR GO; GO:0048261; P:negative regulation of receptor-mediated endocytosis; IEA:Ensembl.
DR GO; GO:0010897; P:negative regulation of triglyceride catabolic process; IEA:Ensembl.
DR GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Ensembl.
DR GO; GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
DR GO; GO:0032489; P:regulation of Cdc42 protein signal transduction; IEA:Ensembl.
DR GO; GO:0019433; P:triglyceride catabolic process; IEA:Ensembl.
DR GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl.
DR Gene3D; 6.10.90.10; Apolipoprotein CIII; 1.
DR InterPro; IPR008403; Apo-CIII.
DR InterPro; IPR038195; Apo_CIII_sf.
DR PANTHER; PTHR14225; APOLIPOPROTEIN C-III; 1.
DR PANTHER; PTHR14225:SF0; APOLIPOPROTEIN C-III; 1.
DR Pfam; PF05778; Apo-CIII; 1.
PE 3: Inferred from homology;
KW Chylomicron {ECO:0000256|ARBA:ARBA00022513};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW VLDL {ECO:0000256|ARBA:ARBA00023313}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..99
FT /note="Apolipoprotein C-III"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014455177"
SQ SEQUENCE 99 AA; 10830 MW; 004D6ED058622C23 CRC64;
MQPRVLLVAA LLSLLASAGA SEAEDTSLLS FMQGYMQHAT KTAKDALTSV QESQMAQQAR
GWVTDGFSSL KDYWSTVKDK FSEFWDLNPE ARPTVAEAA
//
