ID   A0A2K6JRP2_RHIBE        Unreviewed;       773 AA.
AC   A0A2K6JRP2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=F-BAR domain only protein 2 {ECO:0000256|ARBA:ARBA00018998};
GN   Name=FCHO2 {ECO:0000313|Ensembl:ENSRBIP00000001691.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000001691.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000001691.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000001691.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC       {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004283}.
CC   -!- SIMILARITY: Belongs to the FCHO family.
CC       {ECO:0000256|ARBA:ARBA00011064}.
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DR   AlphaFoldDB; A0A2K6JRP2; -.
DR   Ensembl; ENSRBIT00000009346.1; ENSRBIP00000001691.1; ENSRBIG00000007669.1.
DR   GeneTree; ENSGT00940000157105; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   CDD; cd07673; F-BAR_FCHO2; 1.
DR   CDD; cd09267; FCHo2_MHD; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR030122; FCHo2_F-BAR.
DR   InterPro; IPR028565; MHD.
DR   InterPro; IPR018808; Muniscin_C.
DR   PANTHER; PTHR23065:SF8; F-BAR DOMAIN ONLY PROTEIN 2; 1.
DR   PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF10291; muHD; 1.
DR   SMART; SM00055; FCH; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          1..248
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          505..772
FT                   /note="MHD"
FT                   /evidence="ECO:0000259|PROSITE:PS51072"
FT   REGION          284..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..418
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        469..500
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   773 AA;  84587 MW;  F1C2BEC01C5FBDC5 CRC64;
     LIKKYFIANG EKNSGFDVLY HNMKHGQIST KELADFVRER ATIEEAYSRS MTKLAKSASN
     YSQLGTFAPV WDVFKTSTEK LANCHLDLVR KLQELIKEVQ KYGEEQVKSH KKTKEEVAGT
     LEAVQTIQSI TQALQKSKES YNAKCVEQER LKKEGATQRE IEKAAVKSKK ATDTYKLYVE
     KYALAKADFE QKMTETAQKF QDIEETHLIH IKEIIGSLSN AIKEIHLQIG QVHEEFINNM
     ANTTVESLIQ KFAESKGTGK ERPGIKPRKR KTFALPGIIK KEKDAESVEC PDADSLNIPD
     VDEEGYSIKP ETNQNDILSS SGDSDSEDEE PKKYRIEIKP MHPNNSHHTM ASLDELKVSI
     GNITLSPAIS VSTNTFVLCN IKKGTSDLLA WDPLFGPSLD SSSSSLTSSS SARPTTPLSV
     GTIVPPPRPA SRPKLTSGKL SGINEIPRPF SPPVTSNTSP PPAAPLARAE SSSSISSSAS
     LSAANTPTVG VSRGPSPVSL GNQDTLPVAV ALTESVNAYF KGADPTKCIV KITGDMTMSF
     PSGIIKVFTS NPTPAVLCFR VKNISRLEQI LPNAQLVFSD PSQCDSNTKD FWMNMQAVTV
     YLKKLSEQNP AASYYNIDVL KYQVSSNGIQ STPLNLATYW KCSASTTDLR VDYKYNPEAM
     VAPSVLSNIQ VVVPVDGGVT NMQSLPPAIW NAEQMKAFWK LSSISEKSEN GGSGSLRAKF
     DLSEGPSKPM TLAVQFLSEG STLSGVDFEL IGTGYRLSLI KKRFATGRYL ADC
//