ID A0A2K6JRR4_RHIBE Unreviewed; 762 AA.
AC A0A2K6JRR4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Carnitine palmitoyltransferase 1A {ECO:0000313|Ensembl:ENSRBIP00000001717.1};
GN Name=CPT1A {ECO:0000313|Ensembl:ENSRBIP00000001717.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000001717.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000001717.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000001717.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR AlphaFoldDB; A0A2K6JRR4; -.
DR STRING; 61621.ENSRBIP00000001717; -.
DR Ensembl; ENSRBIT00000009471.1; ENSRBIP00000001717.1; ENSRBIG00000007771.1.
DR GeneTree; ENSGT01060000248595; -.
DR OMA; NTEHSWG; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:1990698; F:palmitoleoyltransferase activity; IEA:Ensembl.
DR GO; GO:0009437; P:carnitine metabolic process; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR GO; GO:0001676; P:long-chain fatty acid metabolic process; IEA:Ensembl.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF74; CARNITINE O-PALMITOYLTRANSFERASE 1, LIVER ISOFORM; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16484; CPT_N; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 104..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..47
FT /note="Carnitine O-palmitoyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16484"
FT DOMAIN 174..745
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 462
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 762 AA; 86984 MW; AE26E0A5D1C32F02 CRC64;
MAEAHQAVAF QFTVTPDGID LRLSHEALRQ IYLSGLHSWK KKFIRFKNGI ITGVYPASPS
SWLIVVVGVM TTMYAKIDPS LGIIAKINRT LETTDCMSSQ TKNVVSGVLF GTGLWVALIV
TMRYSLKVLL SYHGWMFAEH GKMSRATKIW MGMVKIFSGR KPMLYSFQTS LPRLPVPAVK
DTVNRYLESV RPLMKEEDFK RMTALAQDFA VSLGPRLQWY LKLKSWWATN YVSDWWEEYI
YLRGRGPLMV NSNYYAMDLL YVLPTHIQAA RAGNAIHAIL LYRRKLDREE IKPASLLGQP
SPPCVLTWLS LYTIQHMRDS KHIVVYHQGR YFKVWLYHDG RLLKPREMEQ QMQRILDNTS
EPQPGEARLA ALTAGDRVPW ARCRQAYFGR GKNKQSLDAV EKAAFFVTLD ETEQGYRTED
PDTSMDSYAK SLLHGQCYDR WFDKSFTFVV FKNGKIGINA EHSWADAPIM AHLWEYVMAT
DSRQLGYAED GHCKGDTNPN IPYPTRLQWD IPEECQEVIE TSLNTANLLA NDVDFHSFPF
VAFGKGIIKK CRTSPDAFVQ LALQLAHYKD MGKFCLTYEA SMTRLFREGR TETVRSCTAE
SCDFVQAMVD PAQTVEQRLK LFKLASEKHQ HMYRLAMTGS GIDRHLFCLY VVSKYLAVES
PFLKEVLSEP WRLSTSQTPP QQVELFDLEN NPEYVSSGGG FGPVADDGYG VSYILVGENL
INFHISSKFS CPETDSHRFG KHLKEAMFDI ITLFGLSSNS KK
//
