ID A0A2K6JRW1_RHIBE Unreviewed; 199 AA.
AC A0A2K6JRW1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=CASP2 and RIPK1 domain containing adaptor with death domain {ECO:0000313|Ensembl:ENSRBIP00000001749.1};
GN Name=CRADD {ECO:0000313|Ensembl:ENSRBIP00000001749.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000001749.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000001749.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000001749.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017723874.1; XM_017868385.1.
DR AlphaFoldDB; A0A2K6JRW1; -.
DR STRING; 61621.ENSRBIP00000001749; -.
DR Ensembl; ENSRBIT00000009642.1; ENSRBIP00000001749.1; ENSRBIG00000008849.1.
DR GeneID; 108527236; -.
DR KEGG; rbb:108527236; -.
DR CTD; 8738; -.
DR GeneTree; ENSGT00390000014448; -.
DR OMA; DGVVIQY; -.
DR OrthoDB; 5396525at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:1905369; C:endopeptidase complex; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0070513; F:death domain binding; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IEA:Ensembl.
DR GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Ensembl.
DR CDD; cd08327; CARD_RAIDD; 1.
DR CDD; cd08319; Death_RAIDD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR042148; CARD_RAIDD.
DR InterPro; IPR037939; CRADD.
DR InterPro; IPR037926; CRADD_Death.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR PANTHER; PTHR15034; DEATH DOMAIN-CONTAINING PROTEIN CRADD; 1.
DR PANTHER; PTHR15034:SF7; DEATH DOMAIN-CONTAINING PROTEIN CRADD; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00531; Death; 1.
DR SMART; SM00114; CARD; 1.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 1..78
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 116..188
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 199 AA; 22682 MW; 70864B53BD8A8909 CRC64;
MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH VQEINAQTTG LRKTMLLLDI
LPSRGPKAFD AFLDSLQEFP WVREKLKKAR KEAMTDLPAG DRLTGIPSHI LNSSPSDRQI
NRLAQRLGPE WEPVVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFVRWRQR FGKQATFQSL
HNGLRAVEVD PSLLLHMLE
//
