ID A0A2K6JXY9_RHIBE Unreviewed; 679 AA.
AC A0A2K6JXY9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSRBIP00000003894.1};
GN Name=ARAP1 {ECO:0000313|Ensembl:ENSRBIP00000003894.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000003894.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000003894.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000003894.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6JXY9; -.
DR Ensembl; ENSRBIT00000020104.1; ENSRBIP00000003894.1; ENSRBIG00000016228.1.
DR GeneTree; ENSGT00940000157424; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13257; PH4_ARAP; 1.
DR CDD; cd13259; PH5_ARAP; 1.
DR CDD; cd17226; RA_ARAP1; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 3.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 1..90
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 194..379
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 412..501
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 514..625
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 679 AA; 77684 MW; F8AB6920600BBE1E CRC64;
MGASRKGKFS RRWCVLSDGV LSYYENERAV TPNGEIRASE IVCLAVPLPD THGFEHTFEV
YTEGERLYLF GLESMEQAHE WVKCIAKAFV PPLAEDLLAR DFERLGRLPY KAGLSLQRAQ
EGWFSLSGSE LRAVFPEGPC EEPLQLRKLQ ELSIQGDSEN QVLVLVERRR TLYIQGERRL
DFMGWLGAIQ KAAASMGDTL SEQQLGDSDI PVIVYRCVDY ITQCGLTSEG IYRKCGQTSK
TQRLLESLRQ DARSVHLKEG EQHVDDVSSA LKRFLRDLPD GLFTRAQRLA WLEASEIEDE
EEKVSRYREL LVRLPPVNRA TVKALVSHLY CVQCFSDTNQ MNVHNLAIVF GPTLFQTDGQ
DYKAGRVVED LINHYVVVFS VDEEELRKQR EEITAIVKMR VAGTASGTQH AGDFICTVYL
EEKKAETEQH VKIPASMTAE ELTLEILDRR NVGIREKDYW TCFEVNEREE AERPLHFAEK
VLPILHGLGT DSHLVVKKHQ AMEAMLLYLA SRVSDTKHGM MKFREDRSLL GLGLPSGGFH
DRYFILNSSC LRLYKEVRSH RPEKEWPVKS LKVYLGVKKK LRPPTCWGFT VVHETEKHEK
QQWYLCCDTQ MELREWFATF LFVQHDGLVW PSEPSRVSRA VPEVRLGSVS LIPLRGSENE
MRRSVAAFTA DPLSLLRNV
//
