ID A0A2K6JZG1_RHIBE Unreviewed; 2283 AA.
AC A0A2K6JZG1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN Name=CACNA1A {ECO:0000313|Ensembl:ENSRBIP00000004389.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000004389.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000004389.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000004389.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. The isoform alpha-1A gives rise to P and/or Q-
CC type calcium currents. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. CACNA1A subfamily. {ECO:0000256|ARBA:ARBA00037936}.
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DR Ensembl; ENSRBIT00000022161.1; ENSRBIP00000004389.1; ENSRBIG00000018638.1.
DR GeneTree; ENSGT00940000156518; -.
DR OMA; KRMCQHR; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005448; CACNA1A.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF3; VOLTAGE-DEPENDENT P_Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01632; PQVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 38..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1107..1126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1146..1167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1179..1196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1241..1263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1353..1376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1432..1453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1539..1557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1635..1659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1796..1830
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 716..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1837..1880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1892..2283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 607..643
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 725..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..808
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..839
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1079
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1892..1915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1946..1960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1971..1990
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2041..2057
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2058..2094
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2095..2132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2145..2160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2266..2283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 216
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 565
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1324
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 2283 AA; 258496 MW; 80256E44594AA158 CRC64;
MILATIIANC IVLALEQHLP DDDKTPMSER LDDTEPYFIG IFCFEAGIKI IALGFAFHKG
SYLRNGWNVM DFVVVLTGIL ATVGTEFDLR TLRAVRVLRP LKLVSGIPSL QVVLKSIMKA
MIPLLQIGLL LFFAILIFAI IGLEFYMGKF HTTCFEEGTD DIQGESPAPC GTEEPARTCP
NGTKCQPYWE GPNNGITQFD NILFAVLTVF QCITMEGWTD LLYNSNDASG NTWNWLYFIP
LIIIGSFFML NLVLGVLSGE FAKERERVEN RRAFLKLRRQ QQIERELNGY MEWISKAEEV
ILAEDETDGE QRHPFDALRR TTIKKSKTDL LNPEEAEDQL ADIASVGSPF ARASIKSAKL
ENSTFFHKKE RRMRFYIRRM VKTQAFYWTV LSLVALNTLC VAIVHYNQPE WLSDFLYYAE
FIFLGLFMSE MFIKMYGLGT RPYFHSSFNC FDCGVIIGSI FEVIWAVIKP GTSFGISVLR
ALRLLRIFKV TKYWASLRNL VVSLLNSMKS IISLLFLLFL FIVVFALLGM QLFGGQFNFD
EGTPPTNFDT FPAAIMTVFQ ILTGEDWNEV MYDGIKSQGG VQGGMVFSIY FIVLTLFGNY
TLLNVFLAIA VDNLANAQEL TKDEQEEEEA ANQKLALQKA KEVAEVSPLS AANMSIAVKE
QQKNQKPAKS VWEQRTSEMR KQNLLASREA LYNEMDPDER WKAAYTRHLR PDMKTHLDRP
LVVDPQENRN NNTNKSRAAE PTVDQRLGQQ RAEDFLRKQT RYHDRARDPS GSAGLDARRP
WAGSQEAELS REGPYGRESD HHAREGSLEQ PGFWEGEVER GKAGDPHRRH VHRQGGSRES
RSGSPRTGAD GEPRRHRTHR RPGEEGPEDK AERRVRHREG SRPLFILFHS LAFLRENQGS
GVPVSGPNLS TTRPIQQDLG RQDPPLAEDI DNMKNNKLAT AESAGPHDSL GHAGLPQSPA
KMGNSTDPGP TPAIPAMATN PQNAASRRMP NNPGNPSNPG PPKTPENSLI VTNPSGTQTN
SAKTARKPDH TTVDIPPACP PPLNHTVVQV NKNANPDPLP KKEDEKKEEE EDDRGEDGPK
PMPPYSSMFI LSTTNPLRRL CHYILNLRYF EMCILMVIAM SSIALAAEDP VQPNAPRNNV
LRYFDYVFTG VFTFEMVIKM IDLGLVLHQG AYFRDLWNIL DFIVVSGALV AFAFTGNSKG
KDINTIKSLR VLRVLRPLKT IKRLPKLKAV FDCVVNSLKN VFNILIVYML FMFIFAVVAV
QLFKGKFFHC TDESKEFEKD CRGKYLLYEK NEVKARDREW KKYEFHYDNV LWALLTLFTV
STGEGWPQVL KHSVDATFEN QGPSPGYRME MSIFYVVYFV VFPFFFVNIF VALIIITFQE
QGDKMMEEYS LEKNERACID FAISAKPLTR HMPQNKQSFQ YRMWQFVVSP PFEYTIMAMI
ALNTIVLMMK VSALHQPPAL LKPHLVPAST LNYFRDAWNI FDFVTVLGSI TDILVTEFGN
NFINLSFLRL FRAARLIKLL RQGYTIRILL WTFVQSFKAL PYVCLLIAML FFIYAIIGMQ
VFGNIGIDVE DEDSDEDEFQ ITEHNNFRTF FQALMLLFRS ATGEAWHNIM LSCLSGKPCD
KNSGIQSREC GNEFAYFYFV SFIFLCSFLM LNLFVAVIMD NFEYLTRDSS ILGPHHLDEY
VRVWAEYDPA AWGRMPYLDM YQMLRHMSPP LGLGKKCPAR VAYKRLLRMD LPVADDNTVH
FNSTLMALIR TALDIKIAKG GADKQQMDAE LRKEMMAIWP NLSQKTLDLL VTPHKSTDLT
VGKIYAAMMI MEYYRQSKAK KLQAMREEQD RTPLMFQRME PPSPTQEGGP GQNALPSAQL
DPGGALMAHE SGLKESPSWV TQRAQEMFQK TGTWSPERGP PTDMPNSQPN SQSVEMREMG
RDGYSDSEHY LPMEGQGRAA SMPRLPAENQ TISDTSPMKR SASVLGPKAR RLDDYSLERV
PPEENQRHHQ RRRDRSHRTS ERSLGRYTDV DTGLGTDLSM TTQSGDLPSK ERDQERGRPK
DRKHRQHHHH HHHHHPPPPD KDRYAQERPD HGRARARDQR WSRSPSEGRE HMAHRQGSSS
VSGSPAPSTS GTSTPRRGRR QLPQTPSTPR PHVSYSPVIR KAGGSGPPQQ QQQQQAVARP
GRAATSGPRR YPGPTAEPLA GDRPPMGGHS SGRSPRMERR VPGPARSESP RACRHGGARW
PASGPQVSER TPRASGPACA SPSRHGRRLP NGYYPAHGLA RPRGPGSRKG LHEPYSESDD
DWC
//
