ID   A0A2K6K0M8_RHIBE        Unreviewed;       851 AA.
AC   A0A2K6K0M8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL3 {ECO:0000313|Ensembl:ENSRBIP00000004812.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000004812.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000004812.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000004812.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   RefSeq; XP_017719440.1; XM_017863951.1.
DR   AlphaFoldDB; A0A2K6K0M8; -.
DR   Ensembl; ENSRBIT00000024122.1; ENSRBIP00000004812.1; ENSRBIG00000020946.1.
DR   GeneID; 108523356; -.
DR   CTD; 26031; -.
DR   GeneTree; ENSGT00940000155957; -.
DR   OMA; XAKYWST; -.
DR   OrthoDB; 960at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          51..146
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          261..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          782..809
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   851 AA;  97210 MW;  6EAEC3B23C5EF9DE CRC64;
     MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK
     KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE
     EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTVTD SASGVFDSIS
     SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL
     QSMDVLHRTY SAPAINAIQG GAFESPKKEK RPQRRWRSRA IGKDAKGTLQ VPKPFSGPVR
     LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA FNIMSAEREK
     LKQLMEQDAS SSPSAQVIGL KNALSSENSR DENRALVHQL SNESRLSITD SLSEFFDAQE
     VLLSPSSSEN EISDDDSYVS DISDNLSLDN LSNDLDNERQ TLGPVLESGA EAKSRRRTCL
     PAPCPSSSNI SLWNILRNNI GKDLSKVAMP VELNEPLNTL QRLCEELEYS ELLDKAAQIP
     SPLERMVYVA AFAISAYASS YYRAGSKPFN PVLGETYECI REDKGFQFFS EQVSHHPPIS
     ACHAESRNFV FWQDVRWKNK FWGKSMEIVP IGTTHVTLPA FGDHFEWNKV TSCIHNILSG
     QRWIEHYGEI VIKNLHDDSC YCKVNFIKAK YWSTNAHEIE GTVFDRSGNA VHRLFGKWHE
     SIYCGGSSSS ACIWRANPMP KGYEQYYGFT QFALELNEMD LSSKSLLPPT DTRFRPDQRF
     LEEGNLEEAE IQKQRIEQLQ RERRRVLEEN HVEHQPRFFR KSNDDSWLSN GTYLELRKDL
     GFSKLDHPVL W
//