ID A0A2K6K1K7_RHIBE Unreviewed; 760 AA.
AC A0A2K6K1K7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=B-cell receptor CD22 {ECO:0000256|ARBA:ARBA00040106};
DE AltName: Full=Sialic acid-binding Ig-like lectin 2 {ECO:0000256|ARBA:ARBA00041781};
GN Name=CD22 {ECO:0000313|Ensembl:ENSRBIP00000005142.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000005142.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000005142.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000005142.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A2K6K1K7; -.
DR Ensembl; ENSRBIT00000025596.1; ENSRBIP00000005142.1; ENSRBIG00000022725.1.
DR GeneTree; ENSGT01010000222294; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd20938; IgC1_CD22_d2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR46958; B-CELL RECEPTOR CD22; 1.
DR PANTHER; PTHR46958:SF1; B-CELL RECEPTOR CD22; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..760
FT /note="B-cell receptor CD22"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014338782"
FT TRANSMEM 601..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..236
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 243..327
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 332..413
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 418..499
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 506..589
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 684..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 85695 MW; 4CC1447B9BB08650 CRC64;
MHLLGPWLLL LVLEYLAFSD SSKWNIDHPE TLYAWEGACV WVPCTYRVLD GALESVILFH
NPEYNKNISK FEGTRLYEST KDGKVPSGQK RVQFLGDKNN NNCTLSIHPV HVNDSGQLGL
RMESKTEKWM ETIHLNVSER PFPPHIQLPP KLQESQEVIL TCSLNFSCYG YQIKLQWLLE
GVPMRQTAVT STSLSTKSVF TRSELKFSPQ WSHHGKIVTC ELHDVDGKVL SEDTVKLNVK
HTPKLEIEVI PSEAIVREGD SVTMTCKVNS SNPEYTTVSW LKDGTPLKEQ NTLTLTLHEV
TKSQSGRYCC RVSNDVGPGT SEKVFLQVQY PPKKVTTVIE NPTPIREGDT VTLSCNYNSS
NPTVNHYEWK PRGAWEEPLL GVLKIQNVGW NNTAIACAAC NNWCSWASPV TLNVLYAPRG
VRVRKIKPFS EIHSGNSVSL QCDFSSSHPK EVQFFWEKNG SLLGKERQLN FDSISPEDAG
SYSCWVNNSI GQTESKAWTL EVLYAPRRLR VSMSQGNQVM EGKTAILTCE SDANPPISSY
TWFDWNNQSL PSSGRMLRLE PVKVQHSGAY WCQGTNRVGK GHSPLFTLTV YYSPETIGRR
VAVGLGSCLA ILILAMCGFK VQRRWKRTQS QQGLQENSSG QSFFVRNKKV RRTPLSEGPH
SLGCYNPMME DGISYATLRF PETNTPRTGD AETSEMQRPP PDCDDTVTYS VLQKRQVGDY
ENVIPDFPED EGIHYSELIQ FGFGERPQAQ ENVDYVILKH
//
