ID A0A2K6K1R6_RHIBE Unreviewed; 2315 AA.
AC A0A2K6K1R6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=POLQ {ECO:0000313|Ensembl:ENSRBIP00000005228.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000005228.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000005228.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000005228.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR Ensembl; ENSRBIT00000025941.1; ENSRBIP00000005228.1; ENSRBIG00000023391.1.
DR GeneTree; ENSGT00940000158694; -.
DR OMA; HNMCQQF; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd18026; DEXHc_POLQ-like; 1.
DR Gene3D; 1.10.3380.20; -; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR046931; HTH_61.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048960; POLQ-like_helical.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF20470; HTH_61; 1.
DR Pfam; PF21099; POLQ_helical; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 108..292
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1530..1553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1707..1728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2080..2101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2194..2225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..956
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2315 AA; 258659 MW; D77360630870FD25 CRC64;
MNLLRRNGKR RRSESGSDSF SGSGGDSSAS PQLLSGSVLS PPPGLGRCLK DRSRQSAAAA
GECKPTVPDY QIDKLLLANW GLPKAVLEKY HSFGVKKMFE WQAECLLLGQ VLEGKNLVYS
APTSAGKTLV AELLILKRVL EMQKKALFIL PFVSVAKEKK YYLQSLFQEV GIKVDGYMGS
TSPSRHFSSL DIAVCTIERA NGLINRLIEE NKMDLLGMVV VDELHMLGDS HRGYLLELLL
TKICYITRKS ASCQADLASS LSNAVQIVGM SATLPNLELV ASWLNAEHYH TDFRPVPLLE
SVKVGNSIYD SSMKLVREFE PMLQVKGDED HVVSLCYETI RDNHSVLLFC PSKTWCEKLA
DIIAREFYNL HHQTEGLVKP SECPPVILEQ KELLEVMDQL RRLPSGLDSV LQKTVPWGVA
FHHAGESILI CKNSEKSKGI ALLQGSLKPV RSCLQRREGE EVTASMIRAI LEIIVGGVAS
TSQDMHTYAA CTFLAASMKE GKQGIQKNQE SVQLGAIEAC VMWLLENEFI QSTEASDGTE
GKVYHPTHLG SATLSSSLSP ADTLDIFADL QRAMKGFVLE NDLHILYLVT PMFEDWTTID
WYRFFCLWEK LPTSMKRVAE LVGVEEGFLA RCVKGKVVTR TERQHRQMAI HKRFFTSLVL
LDLISEVPLR EINQKYGCNR GQIQSLQQSA AVYAGMITVF SNRLGWHNME LLLSQFQKRL
TFGIQRELCD LVRVSLLNAQ RARVLYASGF HTVADLARAN IVEVEVILKN AVPFKSARKA
VDEEEEAVEE RRNMRTIWVT GRKGLTEREA AALIVEEARM ILQQDLVEMG VQWNPCALLH
SSTCSLTHSE SEVKEHTFIS QIKSSYKKLT SNNKSNTIFS DSYIKHSPNI VQDLNKSREH
TSSFNCNFQD GNQEHQRHSI FRARKRASLD INKEKPGASQ NEGKTSKKKV VKTFSEKTKK
APLNFNSEKM SKSFRSWKHR KHPKQSRDSS PLKDSGACRI HLQGQTLSNP SLCEDPFTLD
EKNTEFRNSG PFDKNVSLSG KEKDNKTSFP LQIKQSCSWN ITLTNDNFVE DIVTGSQSKN
VTCQATSVVS EKGRGVAVEA EKINEVLIQN DSKNQNVYVK HCDTHAINQD PQKQSHEQTS
TFTKQKNIIE RQMPCEAVSS YINRDSNVTI NCERIKLNTE ENKPSHFQAL GDDISRTAIP
SEVLPSTGAF SKSGGQHENF LNISRLQEKT GTYTTNKTKN NHVSDCDFED SFYLDTQSEK
IMQQMATENT KLGAKDTNLA VGVMQKSVVQ QNLMNSFQKE CHIPFPAKQH PLGVTKIDHL
DLKTVGTMKQ STDSHGVGIL TPESPIFHSP ILLEENGLCF KKNELSVTDS QLNSFLQGYQ
TQETVKPVIP LIPQKRTPTG IEGECLPVPE TSLNMSDSLL FDSFSDDCLV KEQLPDVQTK
EPFPSEVTSH HFSDSLCLQQ EDLIKKSNVN ENQDTCQQLT FSNDESIIFS EMDSVQMVEA
LDNADIFPVQ EKHHTVVYPR ALELNDPVLD EHHQGDQDGG DQDKRAEKSK LTGTRQNHSF
IWSGASFDLS PGLQRILDKV SSPLENENLK SVTINLSSLN GKYTDLNEEQ EVISNLETNQ
VQGISFSSNS EVKSKIEMLE NNANHGETSS LLPRKESDIV DDNGLIPPTP IPTSASKLTF
PGIIEAPVNL WKTNNVLQPG ESHLFGSSSD IKNHDLSPES RNGFKDNNPI SDTSFSLQLS
QDGLQLTPAS SSSESLAIID VASDQNLFQT FIKEWRCKKR FSISLACEKI RSFTSSKTAT
IGGRFKQANS PQEIPIRDDG FPIKGCDDIL VVGLAVCWGG RDAYYFSLQK EQKHSEISAS
LVPPSLDPSL TLKDRIWHLQ SCLRKESDKE RSVVIYDFIQ SYKILLLSCG ISLEQSYEDP
KVACWLLDPD SQEPTLHSIV TSFLPHELPL LEGMETSQGI QSLGLNAGSE HSGRYRASVE
SILIFNSMNQ LNSLLQKENL QDVFRKVEMP SQYCLALLEL NGIGFSTAEC ESQKHIMQAK
LDAIETQAYQ LAGHSFSFTS SDDIAEVLFL ELKLPPNGEM KNQGSKKTLG STRRGNDNGR
KLRLGRQFST SKDVLNKLKA LHPLPGLILE WRRITNAITK VVFPLQREKR LNPFLGMERI
YPVSQSHTAT GRITFTEPNI QNVPRDFEIK LPTLVGESPP SQATGKGLLP MGRGKNKKGC
SLNPGRQAQM EERAADRGMP FSISMRHAFV PFPGGLILAA DYSQLELRIL AHLSHDRRLI
QALNTGADVF RSIAAEWKMI EPESVGDDLR QQAKQ
//
