ID   A0A2K6K2H1_RHIBE        Unreviewed;       927 AA.
AC   A0A2K6K2H1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Neutral sphingomyelinase activation associated factor {ECO:0008006|Google:ProtNLM};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000005449.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000005449.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000005449.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6K2H1; -.
DR   STRING; 61621.ENSRBIP00000005449; -.
DR   Ensembl; ENSRBIT00000026655.1; ENSRBIP00000005449.1; ENSRBIG00000024116.1.
DR   GeneTree; ENSGT00940000155059; -.
DR   OMA; LLKFPGC; -.
DR   Proteomes; UP000233180; Unplaced.
DR   CDD; cd06071; Beach; 1.
DR   CDD; cd01201; PH_BEACH; 1.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 1.10.1540.10; BEACH domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR000409; BEACH_dom.
DR   InterPro; IPR036372; BEACH_dom_sf.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR023362; PH-BEACH_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR   PANTHER; PTHR13743:SF162; PROTEIN FAN; 1.
DR   Pfam; PF02138; Beach; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM01026; Beach; 1.
DR   SMART; SM00568; GRAM; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF81837; BEACH domain; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50197; BEACH; 1.
DR   PROSITE; PS51783; PH_BEACH; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          209..306
FT                   /note="BEACH-type PH"
FT                   /evidence="ECO:0000259|PROSITE:PS51783"
FT   DOMAIN          310..595
FT                   /note="BEACH"
FT                   /evidence="ECO:0000259|PROSITE:PS50197"
FT   REPEAT          730..760
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          779..820
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          821..862
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   927 AA;  104711 MW;  091DB58E1D9D4DB3 CRC64;
     MTGQARSHPA AEARRLTRKA ARGRGADPYA GARHASPSVR WGGFSLLLLN LEEYYFEQHR
     ANHILHKGSH HERKIRGSLK ICSKSAIFEP DAISQPIIKI PLRDCVKIGK HGENGANRHF
     TKAKSGSISL IFSQVYFIKE HNVVAPYKIE RGKMEYVFEL DVPGKVEDVV ETLLQVSTCW
     VENSKQTEIT AILQSRLART SFDKNRFQNI SEKLHMECKA EMVTPLVTNP GHVCITDTNL
     YFQPLNGYPK PVVQITLQDV RRIYKRRHGL MPLGLEVFCT EDDLCSDIYL KFYEPQDRDD
     LYFYIATYLE HHVAEHTAES YMLQWQRGHL SNYQYLLHLN NLADRSCNDL SQYPVFPWII
     HDYSSSELDL SNPGTFRDLS KPVGALNKER LERLLTRYQE MPEPKFMYGS HYSSPGYVLF
     YLVRIAPEYM LCLQNGRFDN ADRMFNSIAE TWKNCLDGAT DFKELIPEFY GDDVSFLVNS
     LKLDLGKRQG GQMVDDVELP PWASSPEDFL QKSKDALESN YVSEHLHEWI DLIFGYKQKG
     SGAVGAHNVF HPLTYEGGVD LNSIQDPDEK VAMLTQILEF GQTPKQLFVT PHPRRITPKF
     KSLSQTSSYN ATMADSPGEE SFEDLTEESK TLAWNNITKL QLHEHYKIHK EAVTGITVSR
     NGSSVFTTSQ DSTLKMFSKE SKMLQRSISF SNMALSSCLL LPGDATVITS SWDNNVYFYS
     IAFGRRQDTL MGHDDAVSKI CWHDNRLYSA SWDSTVKVWS GVPAEMPGTK RHHFDLLAEL
     EHDVSVDTIS LNPASTLLVS GTKEGTVNIW DLPTATLMHQ IPCHSGIVCD TAFSPDSRHV
     LSTGADGCLN VIDVQTGMLI SSMTSDEPQR CFVWDGNSVL SGSQSGELLV WDLLGAKISE
     RIQGHTAVSS TGGRKTDINI IFGKLQY
//