ID   A0A2K6K488_RHIBE        Unreviewed;       212 AA.
AC   A0A2K6K488;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 20 {ECO:0000256|ARBA:ARBA00019690, ECO:0000256|RuleBase:RU364152};
DE   AltName: Full=Mediator complex subunit 20 {ECO:0000256|RuleBase:RU364152};
GN   Name=MED20 {ECO:0000256|RuleBase:RU364152,
GN   ECO:0000313|Ensembl:ENSRBIP00000006064.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000006064.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000006064.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000006064.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. {ECO:0000256|ARBA:ARBA00025687,
CC       ECO:0000256|RuleBase:RU364152}.
CC   -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC       MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC       MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC       MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC       CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC       module termed the CDK8 module. Mediator containing the CDK8 module is
CC       less active than Mediator lacking this module in supporting
CC       transcriptional activation. Individual preparations of the Mediator
CC       complex lacking one or more distinct subunits have been variously
CC       termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
CC       {ECO:0000256|RuleBase:RU364152}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU364152}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC       {ECO:0000256|ARBA:ARBA00010743, ECO:0000256|RuleBase:RU364152}.
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DR   RefSeq; XP_017733743.1; XM_017878254.1.
DR   AlphaFoldDB; A0A2K6K488; -.
DR   SMR; A0A2K6K488; -.
DR   STRING; 61621.ENSRBIP00000006064; -.
DR   Ensembl; ENSRBIT00000028612.1; ENSRBIP00000006064.1; ENSRBIG00000025814.1.
DR   GeneID; 108533503; -.
DR   KEGG; rbb:108533503; -.
DR   CTD; 9477; -.
DR   GeneTree; ENSGT00390000002060; -.
DR   OMA; QSTFSIC; -.
DR   OrthoDB; 2896803at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0070847; C:core mediator complex; IEA:Ensembl.
DR   GO; GO:0016592; C:mediator complex; IEA:Ensembl.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
DR   InterPro; IPR013921; Mediator_Med20.
DR   PANTHER; PTHR12465:SF0; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20; 1.
DR   PANTHER; PTHR12465; UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49; 1.
DR   Pfam; PF08612; Med20; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU364152};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364152};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Transcription {ECO:0000256|RuleBase:RU364152};
KW   Transcription regulation {ECO:0000256|RuleBase:RU364152}.
SQ   SEQUENCE   212 AA;  23222 MW;  5AA7A39981EB1498 CRC64;
     MGVTCVSQMP VAEGKSVQQT VELLTRKLEM LGAEKQGTFC VDCETYHTAA STLGSQGQTG
     KLMYVMHNSE YPLSCFALFE NGPCLIADTN FDVLMVKLKG FFQSAKASKI ETRGTRYQYC
     DFLVKVGTVT MGPSARGISV EVEYGPCVVA SDCWSLLLEF LQSFLGSHTP GAPAVFGNRH
     DAVYGPADTM VQYMELFNKI RKQQQVPVAG IR
//