ID A0A2K6K5N6_RHIBE Unreviewed; 596 AA.
AC A0A2K6K5N6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Interleukin 1 receptor associated kinase 3 {ECO:0000313|Ensembl:ENSRBIP00000006603.1};
GN Name=IRAK3 {ECO:0000313|Ensembl:ENSRBIP00000006603.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000006603.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000006603.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000006603.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. Pelle subfamily.
CC {ECO:0000256|ARBA:ARBA00008718}.
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DR RefSeq; XP_017727064.1; XM_017871575.1.
DR AlphaFoldDB; A0A2K6K5N6; -.
DR STRING; 61621.ENSRBIP00000006603; -.
DR Ensembl; ENSRBIT00000029765.1; ENSRBIP00000006603.1; ENSRBIG00000026771.1.
DR GeneID; 108529342; -.
DR KEGG; rbb:108529342; -.
DR CTD; 11213; -.
DR GeneTree; ENSGT00940000161222; -.
DR OrthoDB; 2999496at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:Ensembl.
DR GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0045824; P:negative regulation of innate immune response; IEA:Ensembl.
DR GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0010936; P:negative regulation of macrophage cytokine production; IEA:Ensembl.
DR GO; GO:0042177; P:negative regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0043242; P:negative regulation of protein-containing complex disassembly; IEA:Ensembl.
DR GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0001819; P:positive regulation of cytokine production; IEA:Ensembl.
DR GO; GO:0010933; P:positive regulation of macrophage tolerance induction; IEA:Ensembl.
DR GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0032494; P:response to peptidoglycan; IEA:Ensembl.
DR CDD; cd08796; Death_IRAK-M; 1.
DR CDD; cd14160; PK_IRAK3; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042747; IRAK3_death.
DR InterPro; IPR042698; IRAK3_PK.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR24419; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE; 1.
DR PANTHER; PTHR24419:SF7; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 3; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..596
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014452672"
FT DOMAIN 41..106
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT DOMAIN 165..452
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 559..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 596 AA; 67907 MW; 9C7C6C546E5B8D34 CRC64;
MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLAERLSS SWLDVRHIEK
YVDQGKSGTR ELLWSWAQKN KTIGDLLQVL QEMGHRRAIH LITNHGSVLS PSERGYQEGR
FPNILFKETA SVTVDNVLIP EHNEKGILPK SSISFQNIIE GTRNFHKDFL IGEGEIFEVY
RVEIQNLTYA VKLFKQEKKM QCKKHWKRFL SELEVLLLFH HPNILELAAY FTETEKFCLV
YPYMRNGTLF DRLQCVGDTA PLPWHVRISI LIGISKAIHY LHNVQPCSVI CGSISSANIL
LDDQFQPKLT DFAMAHFRSH VEHQSCTINM TSSSSKHLWY MPEEYIRRGK LSIKTDVYSF
GIVIMEVLTG CRVVLDDPKH IQLRDLLIEL MEKRGLDSCL SFLDKKVPPC PRNFSIKLFC
LAGQCAATRA KLRPSMDEVL NTLESTQASL YFAEDPPTSL KSFRCPSPLF LENVPSIPVE
DDESQNNHLL PSDEGLRIER MTQKTPFECS QSEVMFLSLD KKPESKRNEE ACNMPSSSRE
ESWFPKYIVP SQDLRPYEVN MDPSSEAPGH SCRSRPVESS CSFKLSWDEY EQHKKE
//
