ID A0A2K6K5U2_RHIBE Unreviewed; 1742 AA.
AC A0A2K6K5U2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Myosin VA {ECO:0000313|Ensembl:ENSRBIP00000006619.1};
GN Name=MYO5A {ECO:0000313|Ensembl:ENSRBIP00000006619.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000006619.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000006619.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000006619.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSRBIT00000029791.1; ENSRBIP00000006619.1; ENSRBIG00000026539.1.
DR GeneTree; ENSGT00940000155347; -.
DR OMA; GKSKHFE; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF273; UNCONVENTIONAL MYOSIN-VA; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 6.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 6.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 6.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 13..65
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 74..768
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1496..1697
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 603..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..670
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1112..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 920..1103
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1160..1236
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1325..1400
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 603..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 168..175
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1742 AA; 202361 MW; 7C2E5B269A1D0B2B CRC64;
FLFTNLKSKF HPGMFARVWI PDPEEVWKSA ELLKDYKPGD KVLLLHLEEG KDLEYRLDPK
TKELPHLRNP DILVGENDLT ALSYLHEPAV LHNLRVRFID SKLIYTYCGI VLVAINPYEQ
LPIYGEDIIN AYSGQNMGDM DPHIFAVAEE AYKQMARDER NQSIIVSGES GAGKTVSAKY
AMRYFATVSG SASEANVEEK VLASNPIMES IGNAKTTRND NSSRFGKYIE IGFDKRYRII
GANMRTYLLE KSRVVFQAEE ERNYHIFYQL CASAKLPEFK MLRLGNADDF NYTQQGGSPV
IEGVDDAKEM AHTRQACTLL GISESHQMGI FRILAGILHL GNVGFTSRDA DSCTIPPKHE
PLCIFCDLMG VDYEEMCHWL CHRKLATATE TYIKPISKLQ ATNARDALAK HIYAKLFNWI
VDNVNQALHS AVKQHSFIGV LDIYGFETFE INSFEQFCIN YANEKLQQQF NMHVFKLEQE
EYMKEQIPWT LIDFYDNQPC INLIESKLGI LDLLDEECKM PKGTDDTWAQ KLYNTHLNKC
TLFEKPRLSN KAFIIQHFAD KVEYQCEGFL EKNKDTVFEE QIKVLKSSKF KMLPELFQDD
EKAISPTSAT SSGRTPLMRT PAKPTKGRPG QMAKEHKKTV GHQFRNSLHL LMETLNATTP
HYVRCIKPND FKFPFTFDEK RAVQQLRACG VLETIRISAA GFPSRWTYQE FFSRYRVLMK
QKDVLSDRKQ TCKNVLEKLI LDKDKYQFGK TKIFFRAGQV AYLEKLRADK LRAACIRIQK
IIRGWLLRKK YLRMRKAAIT VQRYVRGYQA RCYAKFLRRT KAATIVQKYW RMFVVCRRYK
IRRAATIVLQ SYLRGFLARN RYRKILREHK AVIIQKRVRG WLARTHYKRS MHAIIYLQCC
FRRMMAKREL KKLKIEARSV ERYKKLHIGM ENKIMQLQRK VDEQNKDYKC LVEKLTNLEG
IYNSETEKLR SDLERLQLSE EEAKVATGRV LSLQEEIAKL RKDLEQTRSE KKCIEERADQ
YKQETEQLVS NLKEENTLLK QEKEALNHRI VEQAKEMTET MEKKLVEETK QLELDLNDER
LRYQNLLNEF SRLEERYDDL KEEMTLMVHV PKPGHKRTDS THSSNESEYT FSSEIAEMED
IPSRTEEPSE KKVPLDMSLF LKLQKRVTEL EQEKQVMQDE LDRKEEQVLR SKAKEEERPQ
IRGAELEYES LKRQELESEN KKLKNELNEL RKALSEKSAP EVTAPGAPAY RVLMEQLTSV
SEELDVRKEE VLILRSQLVS QKEAIQPKNT MTDSTILLED VQKMKDKGEI AQAYIGLKET
NRLLESQLQS QKRSHENEAE ALRGEIQSLK EENNRQQQLL AQNLQLPPEA RIEASLQHEI
TRLTNENLDL MEQLEKQDKT VRKLKSMGQM ENISPGQIID EPIRPVNIPR KEKDFQGMLE
YKKEDEQKLV KNLILELKPR GVAVNLIPGL PAYILFMCVR HADYLNDDQK VRSLLTSTIN
SIKKVLKKRG DDFETVSFWL SNTCRFLHCL KQYSGEEGFM KHNTSRQNEH CLTNFDLAEY
RQVLSDLAIQ IYQQLVRVLE NILQPMIGKA RAPLGIAACL SFVPINKYNV SQLEEWLRDK
NLMNSGAKET LEPLIQAAQL LQVKKKTDDD AEAICSMCNA LTTAQIVKVL NLYTPVNEFE
ERVSVSFIRT IQMRLRDRKD SPQLLMDAKH IFPVTFPFNP SSLALETIQI PASLGLGFIS
RV
//
