ID A0A2K6KA45_RHIBE Unreviewed; 318 AA.
AC A0A2K6KA45;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Mitochondrial coenzyme A transporter SLC25A42 {ECO:0000256|ARBA:ARBA00040682};
DE AltName: Full=Solute carrier family 25 member 42 {ECO:0000256|ARBA:ARBA00041886};
GN Name=SLC25A42 {ECO:0000313|Ensembl:ENSRBIP00000008155.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000008155.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000008155.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000008155.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mitochondrial carrier mediating the transport of coenzyme A
CC (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine
CC nucleotides and adenosine 3',5'-diphosphate.
CC {ECO:0000256|ARBA:ARBA00037333}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-dephospho-CoA(in) + ADP(out) = 3'-dephospho-CoA(out) +
CC ADP(in); Xref=Rhea:RHEA:72843, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00036693};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP(in) + ATP(out) = ADP(out) + ATP(in); Xref=Rhea:RHEA:34999,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00024537};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP(out) + AMP(in) = ADP(in) + AMP(out); Xref=Rhea:RHEA:72851,
CC ChEBI:CHEBI:456215, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00036261};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP(out) + CoA(in) = ADP(in) + CoA(out); Xref=Rhea:RHEA:72839,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00036145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP(out) + dADP(in) = ADP(in) + dADP(out);
CC Xref=Rhea:RHEA:72855, ChEBI:CHEBI:57667, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00036435};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine 3',5'-bisphosphate(in) + ADP(out) = adenosine 3',5'-
CC bisphosphate(out) + ADP(in); Xref=Rhea:RHEA:72847, ChEBI:CHEBI:58343,
CC ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036979};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR RefSeq; XP_017708227.1; XM_017852738.1.
DR AlphaFoldDB; A0A2K6KA45; -.
DR STRING; 61621.ENSRBIP00000008155; -.
DR Ensembl; ENSRBIT00000031758.1; ENSRBIP00000008155.1; ENSRBIG00000027977.1.
DR GeneID; 108515657; -.
DR KEGG; rbb:108515657; -.
DR CTD; 284439; -.
DR GeneTree; ENSGT00940000158163; -.
DR OMA; VYERMKW; -.
DR OrthoDB; 1330359at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:InterPro.
DR GO; GO:0043262; F:ADP phosphatase activity; IEA:Ensembl.
DR GO; GO:0015217; F:ADP transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0080122; F:AMP transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0005347; F:ATP transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015228; F:coenzyme A transmembrane transporter activity; IEA:Ensembl.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR002167; GDC-like.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR24089:SF736; MITOCHONDRIAL COENZYME A TRANSPORTER SLC25A42; 1.
DR PANTHER; PTHR24089; SOLUTE CARRIER FAMILY 25; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 31..117
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 129..214
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 224..312
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 318 AA; 35415 MW; 37EB8495DCED0914 CRC64;
MDNGVKEGPV RLREDAEAVL SSSVSSKRDH RQVLSSLLSG ALAGALAKTA VAPLDRTKII
FQVSSKRFSA KEAFRVLYYT YLNEGFLSLW RGNSATMVRV VPYAAIQFSA HEEYKRILGS
YYGFRGEALP PWPRLFAGAL AGTTAASLTY PLDLVRARMA VTPKEMYSNI FHVFIRISRE
EGLKTLYHGF MPTVLGVIPY AGLSFFTYET LKSLHREYSG RRQPYPFERM IFGACAGLIG
QSASYPLDVV RRRMQTAGVT GYPRASIACT LRTIVREEGA VRGLYKGLSM NWVKGPIAVG
ISFTTFDLLQ ILLRHLQS
//
