ID A0A2K6KIL8_RHIBE Unreviewed; 933 AA.
AC A0A2K6KIL8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=NLR family pyrin domain containing 9 {ECO:0000313|Ensembl:ENSRBIP00000011121.1};
GN Name=NLRP9 {ECO:0000313|Ensembl:ENSRBIP00000011121.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000011121.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000011121.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000011121.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR AlphaFoldDB; A0A2K6KIL8; -.
DR STRING; 61621.ENSRBIP00000011121; -.
DR Ensembl; ENSRBIT00000034764.1; ENSRBIP00000011121.1; ENSRBIG00000029422.1.
DR GeneTree; ENSGT00940000163218; -.
DR OMA; PWIDEEY; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:Ensembl.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF13; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 9; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 8.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 1..94
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 146..344
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 933 AA; 107121 MW; 349C9E38C7701633 CRC64;
MAESFFSDFG LLWYLKELRK EEFWKFKELL KQPLEKFELK PIPWAELKKA SKEDVAKLLD
KHYPGKQAWE VTLNLFLQIS RKDLWTKAQE EMRNKLNPYR KHMKEKFQHI WEKETCLQVP
EHFYKETMKN EYKELNGAYT AAARLHTVVL EGSDGIGKTT LLRKVMLDWA EGNLWKDRFT
FVFFLNVYEM NGVTETSLLE LLSRDWPESS ETIEDIFSQP ERILFILDGF EQLKFNLEFK
ADFSDDWRRR QPTPIILSSL LQKKMLPESS LLIALGKLAM QKHYFTLQHP KLIKLSGFTE
SEKKSYFSYY FGEKNKALKV FNFVRDSGPL FILCHNPFIC WLVCTCVKQR LERGEDLEIN
SQNTTSLYAS FLTNVFKAGS QSFLPKVNRA RLKNLCALAA EGVWTYTFVF CHEDLRRNGL
SESEGLMWVG MRLLQRRGDC FTFVHLCIQE FCAAMFYLLK RPKDDPNPAI GSITQLIKAS
MTQPQTHLTQ VGVFTFGISA EEIVSMLETS FGFPLSKDLQ QEITQCLKSL SQCEADREAI
GFQELFVSLF ETQEKEFVTQ VMNFFEEVFI YIGNIQHLAI ASFCLKHCRR LTTLRMCMES
IFPDDSGCAS GYNEKLVYWR ELCSVFITNK NFQILDMENS SLDDASLAIL CKALTQPVCK
LRKLIFTSML NFGHDSELFK AVLHNPHLKL LSLYGTSLSH TDVRHLCETL KHPMCKIEEL
ILGKCDISSE ACEDIASVLA CNSKLKHLSL VENSLRDEGM MLLCEALKHP HCALETLMLM
GCFLTSDSCK DIAAVLICNE KLKTLKLGHN EIGDAGIRQL CAALKHPNCK LEGLGLQTCP
ITRACCGDLA AALVACKTLR SLNLDWITLE PDAVAVLCEA LSHPDCALQM LHKSGFDEET
QKMLMSVEEK MPHLTISHEP WIDEEYKIRG VLL
//
