ID A0A2K6KLJ7_RHIBE Unreviewed; 1225 AA.
AC A0A2K6KLJ7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=ALF transcription elongation factor 3 {ECO:0000313|Ensembl:ENSRBIP00000012128.1};
GN Name=AFF3 {ECO:0000313|Ensembl:ENSRBIP00000012128.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000012128.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000012128.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000012128.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR RefSeq; XP_017703284.1; XM_017847795.1.
DR AlphaFoldDB; A0A2K6KLJ7; -.
DR STRING; 61621.ENSRBIP00000012128; -.
DR Ensembl; ENSRBIT00000035821.1; ENSRBIP00000012128.1; ENSRBIG00000029993.1.
DR GeneID; 108512528; -.
DR CTD; 3899; -.
DR GeneTree; ENSGT00950000182974; -.
DR OMA; NSHRDCK; -.
DR OrthoDB; 4254515at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF16; AF4_FMR2 FAMILY MEMBER 3; 1.
DR Pfam; PF05110; AF-4; 2.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 961..1224
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 23..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..535
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..839
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1225 AA; 133382 MW; 0D6DE45215F541E0 CRC64;
MDSFDLALLQ EWDLESLCVY EPDRNALRRK ERERRNQETQ QDDGTFNSSY SLFSEPYKTN
KGDELSNRIQ NTLGNYDEMK DFLTDRSNQS HLVGVPKPGV PQTPVNKMDE HFVADSRAQT
QPSSIGSTTT STPAAVPVQQ SKRGTMGWQK AGHPPSDGQQ RATQQGSLRT LLGDGVGRQQ
PRAKQVCNVE VGLQTQERPP AMAAKHSSSG HCVQNFPPSL ASKPSLVQQK PTAYVRPMDG
QDQAPDESPK LKSSSETSVH CTSYRGVPAS KPEPARAKAK LSKFSIPKQV EESRSGETNS
CVEEIIREMT WLPPLSAIQA PGKVEPTKFP FPNKDSQLVS SGHNNPKKGD AEPESPDNGT
SNTSMLEDDL KLSSDEEENE QAAQRTALRA LSDSTVVQQP NCRTSVPSSK GSSSSSSSGS
SSSSSDSESS SGSDSETESS SSESEGSKPP HFSSPEAEPA SSNKWQLDKW LNKVNPHKPP
ILIQNESHGP ESNQYYNPVK EDVQDCGKVP DVCQPSLREK EVKSTCKEEQ RPRTANKAPG
SKGVKQKSPP AAVAVAVSAA APPPAVPCAP AENAPAPARR SAGKKPTRRT ERTSAGDGAN
LHRPEEPAAP DALGTSVVVP PEPTKTRPCG NNRASHRKEL RSSVTCEKRR TRGLSRIVPK
SKEFIETESS SSSSSSDSDL ESEQEEYPLS KAQTVAASAS SGSDQRLKEA AANGGNGPRA
PVGSINARTT SDIAKELEEQ FYTLVPFGRN ELLSPLKDSD EVRSLWVKID LTLLSRIPEH
LPQEPGVLSA PATKDSESAP PSHTSDTPAE KALPKSKRKR KCDNEDDYRE IKKAQGEKDS
SSRLATSTSN TLSANHCNMN ISSVAIPINK NEKMLRSPIS PLSDASKHKY TSEDLTSSSR
PNGNSLFTSA SSSKKPKADS QLQPHGGDLT KAAHNNSENI PLHKSRPQTE PWSPGSNGHR
DCKRQKLVFD DMPRSADYFM QEAKRMKHKA DAMVEKFGKA LNYAEAALSF IECGNAMEQG
PMESKSPYTM YSETVELIRY AMRLKTHSGP NATPEDKQLA ALCYRCLALL YWRMFRLKRD
HAVKYSKALI DYFKNSSKAA QAPSPWGASG KSTGTPSPMS PNPSPASSVG SQGSLSNASA
LSPSTIVSIP QRIHQMAANH VSITNSILHS YDYWEMADNL AKENREFFND LDLLMGPVTL
HSSMEHLVQY SQQGLHWLRN SAHLS
//
