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Database: UniProt
Entry: A0A2K6KMD3_RHIBE
LinkDB: A0A2K6KMD3_RHIBE
Original site: A0A2K6KMD3_RHIBE 
ID   A0A2K6KMD3_RHIBE        Unreviewed;       430 AA.
AC   A0A2K6KMD3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=Malic enzyme N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000012437.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000012437.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000012437.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|ARBA:ARBA00008785}.
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DR   AlphaFoldDB; A0A2K6KMD3; -.
DR   Ensembl; ENSRBIT00000036156.1; ENSRBIP00000012437.1; ENSRBIG00000030120.1.
DR   GeneTree; ENSGT00950000183134; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 1.20.1370.30; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23406; MALIC ENZYME-RELATED; 1.
DR   PANTHER; PTHR23406:SF27; NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL; 1.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 2.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          89..250
FT                   /note="Malic enzyme N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01274"
FT   DOMAIN          236..429
FT                   /note="Malic enzyme NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00919"
FT   ACT_SITE        112
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000106-1"
FT   ACT_SITE        183
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000106-1"
FT   BINDING         165
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000106-2"
FT   BINDING         362
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000106-2"
FT   BINDING         407
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000106-2"
SQ   SEQUENCE   430 AA;  48090 MW;  DE9EC5DA3DFFEFAF CRC64;
     MLSRLRVVST TCTLACGHLH IKEKGKPLIL NPRTNKGMAF TLQERQMLGL QGLLPPKIQT
     QDIQALGFHR NLKKITSPLE KCNYIMEIQE RNEKLFYRIL QDDTESLMPI VYTPTVGLVC
     SQYGHFFRRP KGLFMSISDR GHIRSIVDKW PKNHVKVVLV TDGERILGLG DLGVYEMGIP
     VGKMYLCLPV CIDMGTDNIT FLKDTFYMGL YQKQDRTQQY DDLIDEFMKA ITDKYGTAAV
     ALADLLATQK VINKPVSEHK ILFIGTGETT PGIANLIAQK KIWMFDKYGL LVKGRKAKID
     SYQEPFTYPV PESIPDSFED VVNTMRTSTT IGVAGAGHLF TPDVIRAMAS INERPVIFAL
     SNPTAQAECT AEEVYTLTEG KCLFASGSPF GPVKLTDGRI FTPDQGNNVY IFPGNPDFPL
     HTSVFLCVCL
//
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