ID A0A2K6KN26_RHIBE Unreviewed; 1403 AA.
AC A0A2K6KN26;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Patched 1 {ECO:0000313|Ensembl:ENSRBIP00000012682.1};
GN Name=PTCH1 {ECO:0000313|Ensembl:ENSRBIP00000012682.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000012682.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000012682.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000012682.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR Ensembl; ENSRBIT00000036412.1; ENSRBIP00000012682.1; ENSRBIG00000029681.1.
DR GeneTree; ENSGT00940000159011; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 451..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..520
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..759
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 980..1001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1029
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1036..1062
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1074..1094
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1106..1131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 445..551
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1223..1314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1403 AA; 156576 MW; 22B171403F3F6005 CRC64;
MASAGNVAEP QDRGGGGSGC IGAPGRPAGG GRRRRTGGLR RAAAPDRDYL HRPSYCDAAF
ALEQISKGKA TGRKAPLWLR AKFQRLLFKL GCYIQKNCGK FLVVGLLIFG AFAVGLKAAN
LETNVEELWV EVGGRVSREL NYTRQKIGEE AMFNPQLMIQ TPKEEGANVL TTEALLQHLD
SALQASRVHV YMYNRQWKLE HLCYKSGELI TETGYMDQII EYLYPCLIIT PLDCFWEGAK
LQSGTAYLLG KPPLRWTNFD PLEFLEELKK INYQVDSWEE MLNKAEVGHG YMDRPCLNPA
DPDCPATAPT KFNQSECQRW PLDMALVLNG GCHGLSRKYM HWQEELIVGG TVKNSTGKLV
SAHALQTMFQ LMTPKQMYEH FKGYEYVSHI NWNEDKAAAI LEAWQRTYVE VVHQSVTQNS
TQKVLSFTTT TLDDILKSFS DVSVIRVASG YLLMVLPFLA LGVGVDDVFL LAHAFSETGQ
NKRIPFEDRT GECLKRTGAS VALTSISNVT AFFMAALIPI PALRAFSLQA AVVVVFNFAM
VLLIFPAILS MDLYRREDRR LDIFCCFTSP CVSRVIQVEP QAYTDTRDNT RYSPPPPYSS
HSFAHETQIT MQSTVQLRTE YDPHTHVYYT TAEPRSEISV QPVTVTQDTL SCQSPESTSS
TRDLLSQFSD SSLHCLEPRC TKWTLSSFAE KHYAPFLLKP KAKVVVIFLF LGLLGVSLYG
TTRVRDGLDL TDIVPRETRE YDFIAAQFKY FSFYNMYIVT QKADYPNIQH LLYDLHRSFS
NVKYVMLEEN KQLPKMWLHY FRDWLQGLQD AFDSDWETGK IMPNNYKNGS DDGVLAYKLL
VQTGSRDKPV DISQLTKQRL VDADGIINPS AFYIYLTAWV SNDPVAYAAS QANIRPHRPE
WVHDKADYMP ETRLRIPAAE PIEYAQFPFY LNGLRDTSDF VEAIEKVRTI CSNYTSLGLS
SYPNGYPFLF WEQYIGLRHW LLLFISVVLA CTFLVCAIFL LNPWTAGIIV MVLALMTVEL
FGMMGLIGIK LSAVPVVILI ASVGIGVEFT VHVALAFLTA IGDKNRRAVL ALEHMFAPVL
DGAVSTLLGV LMLAGSEFDF IVRYFFAVLA ILTILGVLNG LVLLPVLLSF FGPYPEVSPA
NGLNRLPTPS PEPAPSVVRF AMPPSHMHSG SDSSDSEYSS QTTVSGLSEE LRHYEAQPGA
GGPAHQVIVE ATENPVFAHS TVVHPESRHH PPSNPRQQPH LDSGSLPPGR QGQQPRRDLP
REGLWPPPYR PRRDAFEIST EGCSGPSNRD RWGSRGARSH NPRSPASTAM GSSVPGYCQP
ITTVTASASV TVAVHPPPVP GPGRNPRGGL CPGYEGYPET DHGLFEDPHV PFHVRCERRD
SKVEVIELQD VECEERPRGS SSN
//
