ID A0A2K6KNA8_RHIBE Unreviewed; 2113 AA.
AC A0A2K6KNA8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=FRAS1 related extracellular matrix 1 {ECO:0000313|Ensembl:ENSRBIP00000012728.1};
GN Name=FREM1 {ECO:0000313|Ensembl:ENSRBIP00000012728.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000012728.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000012728.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000012728.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR RefSeq; XP_017722661.1; XM_017867172.1.
DR Ensembl; ENSRBIT00000036460.1; ENSRBIP00000012728.1; ENSRBIG00000030336.1.
DR GeneID; 108526431; -.
DR CTD; 158326; -.
DR GeneTree; ENSGT00940000156990; -.
DR OrthoDB; 5470912at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.60.40.2030; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR045658; FRAS1-rel_N.
DR PANTHER; PTHR45739:SF7; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 1.
DR Pfam; PF19309; Frem_N; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF141072; CalX-like; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS51854; CSPG; 11.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2113
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014401955"
FT REPEAT 295..389
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 412..499
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 520..614
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 641..753
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 775..866
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 958..1060
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1081..1188
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1209..1306
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1327..1419
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1440..1530
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1562..1658
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1994..2101
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
SQ SEQUENCE 2113 AA; 237148 MW; B891F0F04BECCFB7 CRC64;
MNSLSWGTVN ALLLLLLLAW ASPTFISVNR GVRVMKGHSA FLSGDDLKFA IPKEKDACKV
EVVMNEPITQ RVGKLTPQVF DCHFLPNEVK YVHNGCPILD EDTVKLRLYR FTETDTFIET
FILRAYLLEP DCNIIRMSNN VLEVPEFNGL SQAIDKNLLR FDYDRMASLE CTVSLDTART
QLPAHGQMVF GEPRPEEPRG DQPHSFFPAP LGAKLRCPGG SCTPGLKKIG SLKVSCEEFL
LMGLRYQHLH PPSPNIDYIS IQLDLTDTRS KIVYKSESAW LPVYIRAGIP NQIPKAAFMA
MFILEVDQFI LTSLTTSVLD CEEDETPKHL LVFNITKAPL QGYVTHLLDH TRPISSFTWK
DLSDMQIAYQ PPNCSHSERR HDEVELEVYD FFFERSAPMT VHISIRTADT NAPRVSWNTG
LNLLEGQSRA ITWEQFQVVD NDDIGAVRLV TVGGLQHGWL TLRGGKGFLF TVADLQAGVV
RYHHDDSDST KDFVVFRIFD GHHSIRHKFP INILPKDDSP PFLITNVVIE LEEGQTILIQ
GSMLRASDVD ASDDYIFFNI TKPPQAGEIM KKPGPGLIGY PVPGFLQRDL FNGIIYYRHF
GGEIFEDSFQ FVLWDSHEPP NLSVPQVATI HITPVDDQLP KEAPGVSRHL VVKETEVAYI
TKRQLHFIDT ESYDRELVYT ITTPPVFSFS HSHLDAGKLF LVDSIPKVVK NPTALELRSF
TQHAVNYMKV AYMPPMQDIG PHCRDVQFTF SVSNQHGGTL HGICFNITVL PVDNQVPEVF
TNPLKVTEGG QCVISTEHIL ISDADTKLDN IDLSLRGLPL HGRVELNGFP LNSGGTFSWG
DLHTLKVRYQ HDGSEVLQDD ILLEVTDGTN SAEFVLHVKV FPVNDEPPVL KADLTPVMNC
SEGGEVVITS EYIFATDVDS DNLKLMFVIA REPQHGVVRR AGVTVDQFSQ GDVISEAVTY
KHTGPMFVVD EGCSTALTVN HLSATDPDTA SDDLEFVLVS PPQFGYLENI LPSVGFEKSN
IGISIDSFQW KDMNAFCINY VQSRHLRIEP TVDQFTVYAT DGKQRSLEIP FSIIINPTND
EAPDFVVQNI TVCEGQMKEL DSSIISAVDL DIPQDPLLFS IAQKPRHGLL INRQFSKDFP
ENEQPANPDQ KHAPVHSFSM ELLKTGMRLT YVHDDSESLA DDFTIQLSDG KHKILKTISV
EVTPVNDEKP MLSKKAEIAM NMGGTRIISS AVLSAIDEDS PREKIYYVFE RLPQNGQLQF
KIGRDWVPLS SGMKCTQEEV DLNLLRYTHT GAMDSQNQDS FTFYLWDGDN RSPALDCQIT
IKDMEKGDIV ILTKPLVVSK GDRGFLTTTT LLAVDGTDKP EELLYVITSP PRYGQVEYVH
YPGVPITSFS QMDIVGQTVC YVHKSKVTVS SDRFRFIISN GLRTEHGVFE ITLETVDRAL
PVVTRNKGLR LAQGAVGLLS PDLLQLTDPD TAAENLTFLL VQLPQHGQLY LWGTGLLQHN
FTQQDVDSRN VAYRHSGGDS QTDCFTFMAT DRTNQGFVVN GRVWEEPVLF TIQVDQLDKT
APRITLLHSP SQVGLLKNGC YGIYITSRVL KASDPDTEDD QIVFKILQGP KHGHLENTTT
GEFIHEKFNQ KDLNSKTILY IINPSLEVNS DTMEFQIMDP TGNSATPQIL ELKWSHIEWS
QTEYEVCENV GVLPLEIIRR GYSMDSAFVG IKVNQVSAAV GKDFTVTPSK LIQFDPGMST
KMWNIAITYD GLEEDDEVFE VILNSPVNAV LGTKTKAAVK ILDSKGGQCH PSYSSNQSKH
STWEKGIWRL LPPGSSSSTT SGSFHLERRP LPSSMQLAVT RGDTLRGFES TDLSQKKLRT
RGNSKTVRPF SVYRNGMDII YNYHGIVSLK LEDDSFPTHK RKAKVSIISQ PQKTIKVAEL
PQADKVESTT DSHFPRQDLL PSFPKNCTLE LKGLFHFEEG IQKLYQCNGI AWKAWSPQTK
DVEDKSCPAG WHQHSGYCHI VITDQKSTWN AAARACREQY MGNLVTVFSR QHMRWLWDIG
GRKSFWIGLN DQVRPGHWEW IGGEPVAFTN GRRGPSQRSK LGKSCVLVQR QGKWQSKDCR
RAKPHNYVCS RKL
//
