ID   A0A2K6KPL2_RHIBE        Unreviewed;       425 AA.
AC   A0A2K6KPL2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=SEC61 translocon subunit alpha 2 {ECO:0000313|Ensembl:ENSRBIP00000013215.1};
GN   Name=SEC61A2 {ECO:0000313|Ensembl:ENSRBIP00000013215.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000013215.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000013215.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000013215.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003484}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU003484}.
CC   -!- SIMILARITY: Belongs to the SecY/SEC61-alpha family.
CC       {ECO:0000256|ARBA:ARBA00005751, ECO:0000256|RuleBase:RU004349}.
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DR   AlphaFoldDB; A0A2K6KPL2; -.
DR   Ensembl; ENSRBIT00000036977.1; ENSRBIP00000013215.1; ENSRBIG00000030287.1.
DR   GeneTree; ENSGT00390000003721; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3370.10; SecY subunit domain; 1.
DR   InterPro; IPR002208; SecY/SEC61-alpha.
DR   InterPro; IPR030659; SecY_CS.
DR   InterPro; IPR023201; SecY_dom_sf.
DR   InterPro; IPR019561; Translocon_Sec61/SecY_plug_dom.
DR   NCBIfam; TIGR00967; 3a0501s007; 1.
DR   PANTHER; PTHR10906:SF10; PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 2; 1.
DR   PANTHER; PTHR10906; SECY/SEC61-ALPHA FAMILY MEMBER; 1.
DR   Pfam; PF10559; Plug_translocon; 1.
DR   Pfam; PF00344; SecY; 1.
DR   PIRSF; PIRSF004557; SecY; 1.
DR   SUPFAM; SSF103491; Preprotein translocase SecY subunit; 1.
DR   PROSITE; PS00755; SECY_1; 1.
DR   PROSITE; PS00756; SECY_2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU003484};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Translocation {ECO:0000256|ARBA:ARBA00023010,
KW   ECO:0000256|RuleBase:RU003484};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003484};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003484}.
FT   TRANSMEM        27..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        69..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        113..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        138..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        278..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          35..69
FT                   /note="Translocon Sec61/SecY plug"
FT                   /evidence="ECO:0000259|Pfam:PF10559"
SQ   SEQUENCE   425 AA;  47264 MW;  C305F33A7D706B66 CRC64;
     MEVIKPFCAV LPEIQKPERK IQFREKVLWT AITLFIFLVC CQIPLFGIMS SDSADPFYWM
     RVILASNRGT LMELGISPIV TSGLIMQLLA GAKIIEVGDT PKDRALFNGA QKLFGMIITI
     GQAIVYVMTG MYGDPAEMGA GICLLIIIQL FVAGLIVLLL DELLQKGYGL GSGISLFIAT
     NICETIVWKA FSPTTINTGR GTEFEGAVIA LFHLLATRTD KVRALREAFY RQNLPNLMNL
     IATVFVFAVV IYFQGFRVDL PIKSARYRGQ YSSYPIKLFY TSNIPIILQS ALVSNLYVIS
     QMLSVRFSGN FLVNLLGQWA DVSGGGPARS YPVGGLCYYL SPPESMGAIF EDPVHVVVYI
     IFMLGSCAFF SKTWIEVSGS SAKDVAKQLK EQQMVMRGHR DTSMVHELNR PKGKLRRWKG
     EGRHF
//