ID A0A2K6KPR7_RHIBE Unreviewed; 1418 AA.
AC A0A2K6KPR7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Nuclear receptor coactivator {ECO:0000256|PIRNR:PIRNR038181};
GN Name=NCOA3 {ECO:0000313|Ensembl:ENSRBIP00000013269.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000013269.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000013269.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000013269.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038181}.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933, ECO:0000256|PIRNR:PIRNR038181}.
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DR RefSeq; XP_017733360.1; XM_017877871.1.
DR RefSeq; XP_017733362.1; XM_017877873.1.
DR RefSeq; XP_017733363.1; XM_017877874.1.
DR RefSeq; XP_017733364.1; XM_017877875.1.
DR RefSeq; XP_017733365.1; XM_017877876.1.
DR STRING; 61621.ENSRBIP00000013258; -.
DR Ensembl; ENSRBIT00000037023.1; ENSRBIP00000013258.1; ENSRBIG00000030620.1.
DR Ensembl; ENSRBIT00000037034.1; ENSRBIP00000013269.1; ENSRBIG00000030620.1.
DR GeneID; 108533304; -.
DR KEGG; rbb:108533304; -.
DR CTD; 8202; -.
DR GeneTree; ENSGT00950000183021; -.
DR OMA; PELVNQX; -.
DR OrthoDB; 4230728at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0097718; F:disordered domain specific binding; IEA:Ensembl.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:Ensembl.
DR GO; GO:0045618; P:positive regulation of keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd18949; bHLH-PAS_NCoA3_SRC3; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF3; NUCLEAR RECEPTOR COACTIVATOR 3; 1.
DR Pfam; PF07469; DUF1518; 1.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 1.
DR SMART; SM01151; DUF1518; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038181};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038181};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR038181};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR038181}.
FT DOMAIN 25..82
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 117..180
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1260..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..604
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1260..1282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1418 AA; 154393 MW; 95ED32353B5215D7 CRC64;
MSGLGENLDP LATDPRKRKL PCDAPGQGLT CSGEKRRREQ ESKYIEELAE LISANLSDID
NFNVKPDKCA ILKETVRQIR QIKEQGKTIS NDDDVQKADV SSTGQGVIDK DSLGPLLLQA
LDGFLFVVNR DGNIVFVSEN VTQYLQYKQE DLVNTSVYSI LHEEDRKDFL KNLPKSTVNG
VSWTNETQRQ KSHTFNCRML MKTPHDILED INASPEMRQR YETMQCFALS QPRAMMEEGE
DLQSCMICVA RRITTGERAF PSNPESFITR HDLSGKVVNI DTNSLRSSMR PGFEDIIRRC
IQRFFSLNDG QSWSQKRHYQ EAYLNGHAET PVYRFSLADG TIVTAQTKSK LFRNPVTNDR
HGFVSTHFLQ REQNGYRPNP NPVGQGIRPP MAGCNSSVGS MSMSPNQGLQ MPSSRAYGLA
DPSTTGQMSG ARYGGSSNIA SLTPGPGMQS PSSYQNNNYG LSMSSPPHGS PGLAPNQQNI
MISPRNRGSP KIASHQFSPV AGVHSPMGSS GNSGNHSFSS SSLSALQAIS EGVGTSLLST
LSSPGPKLDN SPNMNITQPS KGSSQDSKSP LGFYCDQNPV ESSMCQSNSR DHLSDKESKE
SSVEGSENQR GPLESKGHKK LLQLLTCSSD DRGHSSLTNS PLDSSCKESS VSVTSPSGVS
SSTSGGVSST SNMHGSLLQE KHRILHKLLQ NGNSPAEVAK ITAEATGKDT SSITSCGDGN
VVKQEQLSPK KKENNALLRY LLDRDDPSDA LSKELQPQVE GVDNKISQCA SSTLPSSSQE
KDPKIKTETS EEGSGDLDNL DAILGDLTSS DFYNNSVSSN GSHLGTKQQV FQGTNSLGLK
SPQSVQSIRP PYNRAVSLDS PVSVGSSPPV KNISAFPMLP KQPMLGGNPR MMMDSQENYG
SSMGGPNRNV TVTQTPSSGD WGLPNSKASR MEPMNSNSMG RPGGDYNTSL PRPALGGSMP
TLPLRSNSIP GARPILQPQQ QQQMLQMRPG EIPMGMGANP YGQAAASNQL GSWPDGMLSI
EQVPHGTQNR PLLRNSLDDL VGPPSNLEGQ SDERALLDQL HTLLSNTDAT GLEEIDRALG
IPELVNQGQA LEPKQDAFQG QEAAVMMDQK AGLYGQTYPA QGPPMQGGFH LQGQSPSFNS
MMNQMNQQGN FPLQGMHPRA NIMRPRTNTP KQLRMQLQQR LQGQQFLNQS RQALELKMEN
PTAGGAAVMR PMMQPQQGFL NAQMVAQRSR ELLSHHFRQQ RVAMMMQQQQ QQQQQQQQQQ
QQQQQQQQQQ TQAFSPPPNV TASPSMDGLL AGPAMPQAPP QQFPYQPNYG MGQQPDPAFG
RVSSPPSAMI SSRMGPSQNP MMQHPQAASI YQSSEMKGWP SGNLARNSSF SQQQFAHQGN
PAVYSMVHMN GSSGHMGQMN MNPMPMSGMP MGPDQKYC
//
