ID A0A2K6KQB6_RHIBE Unreviewed; 905 AA.
AC A0A2K6KQB6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=BCAR1 scaffold protein, Cas family member {ECO:0000313|Ensembl:ENSRBIP00000013467.1};
GN Name=BCAR1 {ECO:0000313|Ensembl:ENSRBIP00000013467.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000013467.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000013467.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000013467.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR AlphaFoldDB; A0A2K6KQB6; -.
DR Ensembl; ENSRBIT00000037241.1; ENSRBIP00000013467.1; ENSRBIG00000030766.1.
DR GeneTree; ENSGT00950000183008; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd12001; SH3_BCAR1; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035745; BCAR1_SH3.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR014928; Serine_rich_dom.
DR InterPro; IPR038319; Serine_rich_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654:SF15; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1; 1.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF08824; Serine_rich; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 49..111
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 20..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..135
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 905 AA; 97146 MW; ED3E8110FE74BC95 CRC64;
MPTKPFLSSA LLSWKVLDFS GPGPQETGQP RSCGHWTDGQ GEPPEPAGGP NVLAKALYDN
VAESPDELSF RKGDIMTVLE QDTQGLDGWW LCSLHGRQGI VPGNRLKILV GMYDKKPAGP
GPGPPTIPAQ SQPGLHAPAP PASQYTPMLP TTYQPQPDSV YLVPTPSKAQ QGLYQAPGPS
PQFQSPPAKQ TSTFSKQTPH HQFPSPATDL YQVPPGPGGP AQDIYQVPPS AGMGHDIYQV
PPSMDTRSWE GTKPPAKVVV PTRVGQGYVY EAAQPEQDEY DIPRHLLVPG SQDIYDVPPV
RGLLPSQYGQ EVYDTPPMAV KGPNGRDPLL EVYDVPPSVE KGLPLSSHHA VYDVPPSVSK
DVPDGPLLRE ETYDVPPAFA KAKPFDPART PLVLAVPPPD SPPAEDVYDV PPPAPDLYDV
PPGLRRPGPG TLYDVPRERV LPPEVADGGA VDNGVYAVPP PAEREAPADG KRLSASSTGS
TRSSQSASSL EVAGPGREPL ELEVAVEALA RLQQGVSTTV AHLLDLAGSA GGTGSWRNPS
EPQEPLVQDL QAAVAAVQSA VHELLEFARS AVGNAAHTSD RALHAKLSRQ LQKMEDVHQT
LVAHGQALDA GRGGSGATPE DLDRLVACSR AVPEDAKQLA SFLHGNASLL FRRTKAPAPG
PEGGGTLYPN PTDKTSSIQS RPLPSPPKFT SQDSPDGQYE NSEGGWMEDY DYVHLQGKEE
FEKTQKELLE KGSITRQGKS QLELQQLKQF ERLEQEVSRP IDHDLANWTP AQPLAPGRTG
GLGPSDRQLL LFYLEQCEAN LTTLTNAVDA FFTAVATNQP PKIFVAHSKF VILSAHKLVF
IGDTLFTRRQ SQAVTSTLLC RPSCRGHRGT TKAACLASTH HLRRVKELGH STQQFRRVLG
QLAAA
//
