ID A0A2K6KQM6_RHIBE Unreviewed; 502 AA.
AC A0A2K6KQM6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Single Ig and TIR domain containing {ECO:0000313|Ensembl:ENSRBIP00000013582.1};
GN Name=SIGIRR {ECO:0000313|Ensembl:ENSRBIP00000013582.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000013582.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000013582.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000013582.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6KQM6; -.
DR STRING; 61621.ENSRBIP00000013582; -.
DR Ensembl; ENSRBIT00000037363.1; ENSRBIP00000013582.1; ENSRBIG00000030823.1.
DR GeneTree; ENSGT01090000259985; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR GO; GO:0032682; P:negative regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF19; SINGLE IG IL-1-RELATED RECEPTOR; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 130..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..112
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 174..318
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 349..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 54886 MW; 04C4832391160B3E CRC64;
MPGYKGVCDR APDFLSPSED QVLRPALGSS VALNCTAWVV SGPHCSLPSV QWLKDGLPLG
NGDHYSLHEY SWVKANLSEV LVSSVLGVNM TSAEVYGAFT CSIQNVSSSS VTLQRAGPGT
SRLGGPTSHV AAVLASLLVL LALLLAALLY IKCRLNVLLW YQDAYGEVEM NDGKLYDAYV
SYSDCPEDRK FVNFILKPQL ERRRGYKLFL DDRDLLPRAE PSADLLVNLS RCRRLIVVLS
DAFLSRAWCS HSFREGLCRL LELTRRPIFI TFEGQRRDPA HPALRLLRQH RHLVTLLLWR
PGSVTPSSEF WKELQLALPR KVHYRPVEGD PQTQLQDDKD PMLILRGRVP EGRALDSEVD
PDPEGDLGMP AQPHSPTGAA QHRAEWGEAQ GRGPGGGPRA PAQPLCPGGA WPSVCLGTSW
ASQAITAGDE QGQPLAVGLG QGCGWPPQAY RSPHPRCPGA CLWRAISSTA HEWGLAGRSG
RLGPRLAKLQ CPHRLLLPGV QG
//
