ID A0A2K6KQT0_RHIBE Unreviewed; 1834 AA.
AC A0A2K6KQT0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=DENN domain containing 4C {ECO:0000313|Ensembl:ENSRBIP00000013631.1};
GN Name=DENND4C {ECO:0000313|Ensembl:ENSRBIP00000013631.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000013631.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000013631.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000013631.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 61621.ENSRBIP00000013631; -.
DR Ensembl; ENSRBIT00000037419.1; ENSRBIP00000013631.1; ENSRBIG00000030839.1.
DR GeneTree; ENSGT00940000158215; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0032593; C:insulin-responsive compartment; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0030904; C:retromer complex; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF17; DENN DOMAIN-CONTAINING PROTEIN 4C; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 40..102
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 112..525
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 798..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 958..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1351..1376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1834 AA; 204157 MW; F28737FB5FFFC44F CRC64;
MIEDKGPRVT DYFVVAGLTD TSTLLDQEIN RLDTKSTGPK APITDIAIII KSAGETVPEG
YTCVEATPSA LQANLNYGSL KSPELFLCYK RGRDKPPLTD IGYGDLFSLL YVFLCYKKSV
PASNAIAYKA GLIFRYPEED YESFPLSESD VPLFCLPMGA TIECWDPETK YPLPVFSTFV
LTGSSAKKVC FASKYKKLGR VQWLTPVIRA LWKAEVDLLK PMMHFRKVIM MFISNFFSRH
ISHFMQNIPF PSPQRPRILV QFTVIYFSLF FPSGANFSTL LMNLGPENCA TLLLFVLLES
KILLHSLRPA VLTGVAEAVV AMIFPFQWQC PYIPLCPLSL AAVLSAPLPF IVGVDSRYFD
LHDPPQDVVC IDLDTNMLYV SDEKKNMNWK QLPKKPCKNL LSTLKKLYPQ LSSVHRKTQE
GSAIDMTPIE ADFSWQKKMT QLEMEIQEAF LRFMASILKG YRTFLRPITE APSNKATAAD
SLFDRQGFLK SRDRAYAKFY TLLSKTQIFI RFIEECSFVS DKDTGLAFFD DCIEKLFPDK
GTEKSEKVDF DSAEDTRLIE LDDSQKSEHT VFIMPPEPPP DDGKDLSPKY SYKYFPRLDL
KLFDRPQELK LCFSRHPTGN SITKSPALMA KRTKQEIKTA HKLAKRCYTN PPQWAKCLFS
HCYSLWFICL PAYVRVSHSK VRALQQAYDV LIKMRKTDVD PLDEVCYRVV MQLCGLWGHP
VLAVRVLFEM KTARIKPNAI TYGYYNKVVL ESPWPSSTRS GIFLWTKVRN VVHGLAQFRQ
PLKKTVQRSQ VSSISALQNV TGGSDGDTVS HGSVDSSNDA NNGEHTVFVR DLIRLESIDN
HSSTGGQSDQ GYGSKDELIK DDAEIHVPEE QAAKELITKT KMQTEEVCDA SAIVAKHSQP
SPEPHSPTES PAWGSSIVKV PSGIFDISSR KSSTGSISNV LVSTQDPVED AVFGEATNLK
KNGDRGEKRQ KHFPERSCSF SSESRAGMLL KKSSLDSNSS EMAIMMGADA KILTAALTCP
KTSPLHVART HTFENVSCHL PDSRTCVSES TWNPEHISSP VPEMVEESQE LLEPVTDDIP
KTTAAVDTYE SLLSDSNSNQ SRDLKTGSKD LRNKRSSLYG IAKEVERKDV ETGLDPLSLL
ATECSGGETL DSEDKLFSPV IARNLADEIE SYMNLKSPLG SKSSSMELHG EENRESGMTT
AFIHALERRS SLPLDHGSPA QENPESEKSS PAVSRSKTFT GRFKQQTPSR THKERSTSLS
ALIRSSPHGS LGSVVNSLSG LKLDNILSGP KIDVLKSGMK QAATVASKMW VAVASAYSYS
DDEEETNRDY SFPAGLEDHI LGENISPNTS LSGLVPSELT QSNTSLGSSS SSGDVGKLHY
PTGEVPFPRG MKGQDFEKSD HGSSQNTSMS SIYQNCAMEV LMSSCSQCRA CGTLVYDEEI
MAGWTADDSN LNTACPFCKS NFLPLLNIEF KDLRGSASFF LKPSTSGDSL QSGSIPLANE
SLEHKPVSSL AEPDLINFMD FPKHNQTITE ETGSAVEPSD EIKRASGDVQ TMKISSVPNS
LSKRNVSLTR SHSVGGPLQN IDFTQRPFHG ISTVSLPNSL KRPNPPPVSV PYLSPLVLRK
ELESLLENEG DQVIHTSSFI NQHPIIFWNL VWYFRRLDLP SNLPGLILTS EHCNEGVQLP
LSSLSQDSKL VYIQLLWDNI NLHQEPREPL YVSWRNFNSE KKSSLLSEEQ EATSTLVETI
RQSIQHNNVL KPINLLSQQM KPGMKRQRSL YREILFLSLV SLGRENIDIE AFDNEYGIAY
NSLSSEILEK LQKIDAPPSA SVEWCRKCFG APLI
//
