ID A0A2K6KRM2_RHIBE Unreviewed; 1990 AA.
AC A0A2K6KRM2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Unc-13 homolog B {ECO:0000313|Ensembl:ENSRBIP00000013908.1};
GN Name=UNC13B {ECO:0000313|Ensembl:ENSRBIP00000013908.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000013908.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000013908.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000013908.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the unc-13 family.
CC {ECO:0000256|ARBA:ARBA00005823}.
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DR Ensembl; ENSRBIT00000037726.1; ENSRBIP00000013908.1; ENSRBIG00000030923.1.
DR GeneTree; ENSGT00940000154929; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd20859; C1_Munc13-2-like; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF8; PROTEIN UNC-13 HOMOLOG B; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 857..907
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 963..1087
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1393..1536
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1643..1785
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1818..1945
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1990 AA; 222864 MW; 691DA4711EC1D1CE CRC64;
MKRLLQESEE EIMVTLGPSS RLSPDKAKAE TMCSTKSKSS GPAGSLPEDN SLPPCCGSAA
LAIGGDRDGD LAQLCSFGQQ NNSQRSLGST AYVSGSGSQD PSSVSITTSC HELPEGNQAK
TLLSRGHGQG CSREQREPLG DVVEYIIREL QGISRLQTEI AELRQHLSQV RGSVDEVSSC
VDSVLSEIEG LQVSSCSLAK VCEGEKAQEP HADRPSEEAI LYLYGLPEQD GENTMELVES
FLAKHLCVNG MQCNRYIKKA YRAGTSPCPR PTVVKLAHLE HRDFILQKSI LLQNMGVRIA
TREEPSCPKA YKNPQKESIS FFQQQHQDYS RTSLNQDEPV LQMETGDRGP ITGTYQMKAQ
DQHREHQAPE QQGPCFLLQN NLSKESDVPK LGDEIKGTSR TSQVISGSCD ELSEKKPSLS
TPHQSEEPAV VLISKEEDSG KSQFFKQYSH KGEAYKVGKP ENDCHDKSEA SSCLSLSGLL
KTERINTEDK LLGCEAGLDI LSSKELEDLL ADKSRRLTAL SCDSMMEEII IGPETLNDMI
HIDLNEEEEC AAHVLKDVFD KSSCVLGGSQ EDEDVEIKFY TSKLGRAIHH FRSALQGVFQ
KLENSGSISP EDLESNESGS QSENSDRLLG TVSSGGAQDC SLESPGSQGS ESLLSVVSGG
VGISTQGEQT PQDPSNFSLA SNNSLPSFAL APCLGSETCS RPESPKQGRL SLEQVCTETI
YLNKCINNFK NVLREKRLRQ KKLLHELVQK ANRLSVEDMH SEGKRGALQI PDDGDPSLPQ
WLPEGPAGGL YGIDSMPDLR RKKPLPLVSD LSLVQSRKAG ITSAMATRTS LKDEELKSHV
YKKTLQALIY PISCTTPHNF EVWTATTPTY CYECEGLLWG IARQGMRCSE CGVKCHEKCQ
DLLNADCLQR AAEKSCKHGA EDRTQNIIMA MKDRMKIRER NKPEIFEVIR DVFTVSKAAH
VQQMKTVKQS VLDGTSKWSA KITITVVCAQ GLQAKDKTGS SDPYVTVQVG KTKKRTKTIF
GNLNPVWEEK FHFECHNSSD RIKVRVWDED DDIKSRVKQR LKRESDDFLG QTIIEVRTLS
GEMDVWYNLE KRTDKSAVSG AIRLQISVEI KGEEKVAPYH VQYTCLHENL FHYLTDIQGS
GGVRIPEARG DDAWKVYFDE TAQEIVDEFA MRYGIESIYQ AMTHFACLSS KYMCPGVPAV
MSTLLANINA YYAHTTASTN VSASDRFAAS NFGKERFVKL LDQLHNSLRI DLSTYRNNFP
AGSPERLQDL KSTVDLLTSI TFFRMKVQEL QSPPRASQVV KDCVKACLNS TYEYIFNNCH
DLYSHQYQLK QELPPEEQGP SIRNLDFWPK LITLIVSIIE EDKNSYTPVL NQFPQELNVG
KVSAEVMWHL FAQDMKYALE EHEKDRLCKS ADYMNLHFKV KWLHNEYVRD LPVLQGQVPE
YPAWFEQFVL QWLDENEDVS LEFLHGALER DKKDGFQQTS EHALFSCSVV DVFTQLNQSF
EIIRKLECPD PSILAHYMRR FAKTIGKVLM QYADILSKDF PTYCTKEKLP CILMNNMQQL
RVQLEKMFEA MGGKELDLEA ADSLKELQVK LNTVLDELSM VFGNSFQVRI DECVRQMADI
LGQVRGTGNA SPDARASATQ DADSVLRPLM DFLDGNLTLF ATVCEKTVLK RVLKELWRVV
MNTMERMIVL PPLTDQTGTQ MIFTAAKELS HLSKLKDHMV REETRNLTPK QCAVLDLALD
TIKQYFHAGG NGLKKTFLEK SPDLQSLRYA LSLYTQTTDT LIKTFVRSQT TQVHDGKGIR
FTANEDIRPE KGSGVDDPVG EVSIQVDLFT HPGTGEHKVT VKVVAANDLK WQTAGMFRPF
VEVTMVGPHQ SDKKRKFTTK SKSNNWAPKY NETFHFLLGN EEGPESYELQ ICVKDYCFAR
EDRMLGLAVM PLRDVTAKGS CACWCPLGRK IHMDETGLTI LRILSQRSND EVAREFVKLK
SESRSTEEGS
//