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Database: UniProt
Entry: A0A2K6KRM2_RHIBE
LinkDB: A0A2K6KRM2_RHIBE
Original site: A0A2K6KRM2_RHIBE 
ID   A0A2K6KRM2_RHIBE        Unreviewed;      1990 AA.
AC   A0A2K6KRM2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Unc-13 homolog B {ECO:0000313|Ensembl:ENSRBIP00000013908.1};
GN   Name=UNC13B {ECO:0000313|Ensembl:ENSRBIP00000013908.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000013908.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000013908.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000013908.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the unc-13 family.
CC       {ECO:0000256|ARBA:ARBA00005823}.
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DR   Ensembl; ENSRBIT00000037726.1; ENSRBIP00000013908.1; ENSRBIG00000030923.1.
DR   GeneTree; ENSGT00940000154929; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098793; C:presynapse; IEA:UniProt.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   CDD; cd20859; C1_Munc13-2-like; 1.
DR   CDD; cd04027; C2B_Munc13; 1.
DR   CDD; cd08395; C2C_Munc13; 1.
DR   Gene3D; 1.10.357.50; -; 1.
DR   Gene3D; 1.20.58.1100; -; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR010439; MUN_dom.
DR   InterPro; IPR014770; Munc13_1.
DR   InterPro; IPR014772; Munc13_dom-2.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR027080; Unc-13.
DR   InterPro; IPR037302; Unc-13_C2B.
DR   PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR   PANTHER; PTHR10480:SF8; PROTEIN UNC-13 HOMOLOG B; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF06292; MUN; 1.
DR   PRINTS; PR00360; C2DOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM01145; DUF1041; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS51258; MHD1; 1.
DR   PROSITE; PS51259; MHD2; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   3: Inferred from homology;
KW   Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          857..907
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          963..1087
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          1393..1536
FT                   /note="MHD1"
FT                   /evidence="ECO:0000259|PROSITE:PS51258"
FT   DOMAIN          1643..1785
FT                   /note="MHD2"
FT                   /evidence="ECO:0000259|PROSITE:PS51259"
FT   DOMAIN          1818..1945
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          606..681
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          758..778
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..415
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1990 AA;  222864 MW;  691DA4711EC1D1CE CRC64;
     MKRLLQESEE EIMVTLGPSS RLSPDKAKAE TMCSTKSKSS GPAGSLPEDN SLPPCCGSAA
     LAIGGDRDGD LAQLCSFGQQ NNSQRSLGST AYVSGSGSQD PSSVSITTSC HELPEGNQAK
     TLLSRGHGQG CSREQREPLG DVVEYIIREL QGISRLQTEI AELRQHLSQV RGSVDEVSSC
     VDSVLSEIEG LQVSSCSLAK VCEGEKAQEP HADRPSEEAI LYLYGLPEQD GENTMELVES
     FLAKHLCVNG MQCNRYIKKA YRAGTSPCPR PTVVKLAHLE HRDFILQKSI LLQNMGVRIA
     TREEPSCPKA YKNPQKESIS FFQQQHQDYS RTSLNQDEPV LQMETGDRGP ITGTYQMKAQ
     DQHREHQAPE QQGPCFLLQN NLSKESDVPK LGDEIKGTSR TSQVISGSCD ELSEKKPSLS
     TPHQSEEPAV VLISKEEDSG KSQFFKQYSH KGEAYKVGKP ENDCHDKSEA SSCLSLSGLL
     KTERINTEDK LLGCEAGLDI LSSKELEDLL ADKSRRLTAL SCDSMMEEII IGPETLNDMI
     HIDLNEEEEC AAHVLKDVFD KSSCVLGGSQ EDEDVEIKFY TSKLGRAIHH FRSALQGVFQ
     KLENSGSISP EDLESNESGS QSENSDRLLG TVSSGGAQDC SLESPGSQGS ESLLSVVSGG
     VGISTQGEQT PQDPSNFSLA SNNSLPSFAL APCLGSETCS RPESPKQGRL SLEQVCTETI
     YLNKCINNFK NVLREKRLRQ KKLLHELVQK ANRLSVEDMH SEGKRGALQI PDDGDPSLPQ
     WLPEGPAGGL YGIDSMPDLR RKKPLPLVSD LSLVQSRKAG ITSAMATRTS LKDEELKSHV
     YKKTLQALIY PISCTTPHNF EVWTATTPTY CYECEGLLWG IARQGMRCSE CGVKCHEKCQ
     DLLNADCLQR AAEKSCKHGA EDRTQNIIMA MKDRMKIRER NKPEIFEVIR DVFTVSKAAH
     VQQMKTVKQS VLDGTSKWSA KITITVVCAQ GLQAKDKTGS SDPYVTVQVG KTKKRTKTIF
     GNLNPVWEEK FHFECHNSSD RIKVRVWDED DDIKSRVKQR LKRESDDFLG QTIIEVRTLS
     GEMDVWYNLE KRTDKSAVSG AIRLQISVEI KGEEKVAPYH VQYTCLHENL FHYLTDIQGS
     GGVRIPEARG DDAWKVYFDE TAQEIVDEFA MRYGIESIYQ AMTHFACLSS KYMCPGVPAV
     MSTLLANINA YYAHTTASTN VSASDRFAAS NFGKERFVKL LDQLHNSLRI DLSTYRNNFP
     AGSPERLQDL KSTVDLLTSI TFFRMKVQEL QSPPRASQVV KDCVKACLNS TYEYIFNNCH
     DLYSHQYQLK QELPPEEQGP SIRNLDFWPK LITLIVSIIE EDKNSYTPVL NQFPQELNVG
     KVSAEVMWHL FAQDMKYALE EHEKDRLCKS ADYMNLHFKV KWLHNEYVRD LPVLQGQVPE
     YPAWFEQFVL QWLDENEDVS LEFLHGALER DKKDGFQQTS EHALFSCSVV DVFTQLNQSF
     EIIRKLECPD PSILAHYMRR FAKTIGKVLM QYADILSKDF PTYCTKEKLP CILMNNMQQL
     RVQLEKMFEA MGGKELDLEA ADSLKELQVK LNTVLDELSM VFGNSFQVRI DECVRQMADI
     LGQVRGTGNA SPDARASATQ DADSVLRPLM DFLDGNLTLF ATVCEKTVLK RVLKELWRVV
     MNTMERMIVL PPLTDQTGTQ MIFTAAKELS HLSKLKDHMV REETRNLTPK QCAVLDLALD
     TIKQYFHAGG NGLKKTFLEK SPDLQSLRYA LSLYTQTTDT LIKTFVRSQT TQVHDGKGIR
     FTANEDIRPE KGSGVDDPVG EVSIQVDLFT HPGTGEHKVT VKVVAANDLK WQTAGMFRPF
     VEVTMVGPHQ SDKKRKFTTK SKSNNWAPKY NETFHFLLGN EEGPESYELQ ICVKDYCFAR
     EDRMLGLAVM PLRDVTAKGS CACWCPLGRK IHMDETGLTI LRILSQRSND EVAREFVKLK
     SESRSTEEGS
//
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