ID A0A2K6KSE4_RHIBE Unreviewed; 432 AA.
AC A0A2K6KSE4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Growth differentiation factor 7 {ECO:0000313|Ensembl:ENSRBIP00000014189.1};
GN Name=GDF7 {ECO:0000313|Ensembl:ENSRBIP00000014189.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000014189.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000014189.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000014189.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6KSE4; -.
DR STRING; 61621.ENSRBIP00000014189; -.
DR Ensembl; ENSRBIT00000038019.1; ENSRBIP00000014189.1; ENSRBIG00000031200.1.
DR GeneTree; ENSGT00940000160140; -.
DR OMA; RAPRAFC; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0032924; P:activin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
DR GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0048853; P:forebrain morphogenesis; IEA:Ensembl.
DR GO; GO:0022612; P:gland morphogenesis; IEA:Ensembl.
DR GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR GO; GO:0060571; P:morphogenesis of an epithelial fold; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; IEA:Ensembl.
DR GO; GO:2001051; P:positive regulation of tendon cell differentiation; IEA:Ensembl.
DR GO; GO:0048608; P:reproductive structure development; IEA:Ensembl.
DR GO; GO:0021509; P:roof plate formation; IEA:Ensembl.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; IEA:Ensembl.
DR CDD; cd13766; TGF_beta_GDF5_6_7; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF160; GROWTH_DIFFERENTIATION FACTOR 7; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 300..432
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 274..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 46043 MW; 6C69B1C6024EECD5 CRC64;
MDHECRPPRC APWLLSACRP RDGLEAAAVL TSERGWPAVG AAAVPAAAVS RARAPRRAAG
SGFRNGSVVP HHFMMSLYRS LAGRAPAGAA ALSALGHGRA DTITGFTDQA TQDESAAETG
QSFLFDVSSL NDADEVVGAE LRVLRRGSPE PGPGSSTSPP LLLLSTCPGA ARAPRLLYSR
AADPQVGQRW EVFDVADAMR RHRREPRPPR AFCLLLRAVA GPVRSPLALR RLGFGWPGGG
GFAAEERALL VVSSRTQRKE SLFREMRAQA RALGAALAAQ PPSDPGTGTG SPRAVTAGRR
RRRTALAGTR TAQGSGGGAG RGHGRRGRSR CSRKPLHVDF KELGWDDWII APLDYEAYHC
EGVCDFPLRS HLEPTNHAII QTLLNSMAPD AAPASCCVPA RLSPISILYI DAANNVVYKQ
YEDMVVEACG CR
//
